JCEM：男性的身体组成影响性激素水平

先前的研究表明在男性，睾酮（T）与瘦体重呈正相关，与体脂含量呈负相关；然而，这些关联的方向性，以及睾酮与其他激素包括雌二醇（E2）和性激素结合球蛋白(SHBG)的关系尚不清楚。为此，来自美国马萨诸塞州新英格兰研究院的Andre B Araujo教授及其团队进行了一项研究，该研究发现男性的身体组成影响性激素水平。该研究结果在线发表在2013年4月26日的美国《临床内分泌代谢杂志》（The journal of endocrinology & metabolism）上。

该研究在波士顿地区社区健康/骨骼调查中，检查30至79岁男性的雌二醇、睾酮、性激素结合球蛋白以及雌二醇/睾酮比值与身体组成的横向和纵向相关性。通过双能X线吸收法在基线测量整体、躯干以及四肢的瘦体重和体脂含量，并在基线和随访期间测量体重和腰/臀围。使用皮尔森偏相关系数评估各自身体组成的测量值与激素变量对数转化之间的线性关系。

该研究结果表明，在821例男性的横断面分析中，睾酮、计算出的游离睾酮和性激素结合球蛋白与体脂含量、体重、体重指数、腰/臀围和腰臀比呈负相关，多元校正相关系数从－0.13至－0.37。计算出的游离雌二醇与整体（r=0.13）和躯干（r=0.15）体脂含量百分数呈正相关，且雌二醇/睾酮与所有检查测量值呈正相关（r=0.13–0.40）。基线激素水平与平均随后4.8年后体重、体重指数、腰/臀围或腰臀比变化之间的多元校正纵向相关性没有意义。

该研究发现，在男性，激素水平，包括雌二醇、睾酮以及雌二醇/睾酮与身体成分测量之间有显著横向相关。纵向分析显示基线激素水平对人体测量的变化没有影响，暗示身体组成影响激素水平，但反过来不成立。

与性激素相关的拓展阅读：

• Science：肠道微生物通过性激素来影响自身免疫风险
• Diabetes ：男性雄性激素含量低或可增糖尿病风险
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Sex Steroid Hormone Levels and Body Composition in Men
Background
Previous studies indicate that testosterone (T) is positively correlated with lean mass and inversely correlated with fat mass in men; however, the directionality of these associations, as well as the association with other hormones including estradiol (E2) and SHBG, is unclear.
Methods
We examined cross-sectional and longitudinal associations of E2, T, SHBG, and E2/T ratio with body composition among men ages 30 to 79 in the Boston Area Community Health/Bone Survey. Total, trunk, and appendicular lean and fat mass were measured by dual-energy x-ray absorptiometry at baseline, and weight and waist/hip circumference were measured at baseline and follow-up. Partial Pearson correlation coefficients were used to estimate the linear relationship between each body composition measure and log-transformed hormone variable.
Results
In cross-sectional analyses of 821 men, T, calculated free T, and SHBG were inversely correlated with fat mass, weight, body mass index, waist/hip circumference, and waist-to-hip ratio, with multivariable-adjusted correlations ranging from −0.13 to −0.37. Calculated free E2 was positively correlated with percentage total (r = .13) and trunk (r = .15) fat mass, and E2/T was positively correlated with all measures examined (r = .13–.40). There were no significant multivariable-adjusted longitudinal associations between baseline hormone levels and change in weight, body mass index, waist/hip circumference, or waist-to-hip ratio after an average follow-up of 4.8 years.
Conclusions
We observed significant cross-sectional associations between hormone levels, including E2, T, and E2/T, and body composition measures in men. Longitudinal analyses showing no influence of baseline hormone levels on change in anthropometric measures imply that body composition affects hormone levels and not the reverse.