Thorax:引起儿童下呼吸道症状的病毒分析!

2017-12-17 xing.T MedSci原创

由此可见,呼吸道合胞病毒、人类偏肺病毒与儿童托管社区内的ARIs和下呼吸道症状之间较强的相关性表示针对这两种病毒的疫苗研制成功应该可以带来大量的健康益处。

病毒性急性上呼吸道感染(ARIs)是导致儿童患病的主要原因。基于敏感分子的实验有助于病毒检测,但阳性检测结果的临床意义仍不确定,因为一些病毒可能在急性发病患儿和健康儿童中均可被发现。近日,胸部疾病领域权威杂志Thorax上发表了一篇研究文章,研究人员描述了病原相关的呼吸道病毒,并量化健康儿童2岁内ARIs的病毒特异性归因危险度。

研究人员对2010年9月至2014年10月期间在澳大利亚布里斯班市出生的一百五十八名足月新生儿进行纵向、社区出生队列研究。研究人员捕捉了儿童从出生到两岁期间的呼吸道症状,并通过PCR检测了父母每周采集的鼻拭子样本中的17种呼吸道病毒,可以在接触的病毒中计算病毒特异性归因分数(AFE)确定病毒阳性儿童ARI症状可能是由于特定的病毒所致的比例。

研究人员分析了8100份鼻拭子样品,2646份(32.7%)病毒阳性(共检测到275种病毒,3.4%),阳性样本中人类鼻病毒占2058/2646(77.8%)。在ARI发作期检测到病毒感染的有1154/1530例(75.4%),984/4308份(22.8%)拭子在无症状期中检测到病毒。呼吸道合胞病毒 (AFE为68% (95%可信区间为45%-82%)) 以及人偏肺病毒 (AFE为69% (95%可信区间为43%-83%)) 与较高的下呼吸道感染风险密切相关。

由此可见,呼吸道合胞病毒、人类偏肺病毒与儿童托管社区内的ARIs和下呼吸道症状之间较强的相关性表示针对这两种病毒的疫苗研制成功应该可以带来大量的健康益处。

原始出处:

Mohinder Sarna, et al. Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort.Thorax. 2017. http://dx.doi.org/10.1136/thoraxjnl-2017-210233

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    2017-12-20 stupidox

    有意思,学习了。

    0

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    2017-12-19 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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    2017-12-19 zhmscau
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    2017-12-19 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2009572, encodeId=70a220095e2d6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Mar 15 20:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270820, encodeId=faa52e082049, content=有意思,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:26:07 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270554, encodeId=87572e0554bd, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:30:54 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282436, encodeId=309e1282436a2, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Dec 19 08:39:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270488, encodeId=28a92e0488ba, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Dec 19 06:47:49 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270343, encodeId=94da2e03435b, content=科普去, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Mon Dec 18 12:25:58 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270154, encodeId=45942e01549a, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 17 19:17:35 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270146, encodeId=1d7c2e01465b, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Dec 17 19:05:43 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270143, encodeId=dc982e0143cd, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 17 18:57:23 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-18 smartxiuxiu

    科普去

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2009572, encodeId=70a220095e2d6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Mar 15 20:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270820, encodeId=faa52e082049, content=有意思,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:26:07 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270554, encodeId=87572e0554bd, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:30:54 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282436, encodeId=309e1282436a2, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Dec 19 08:39:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270488, encodeId=28a92e0488ba, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Dec 19 06:47:49 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270343, encodeId=94da2e03435b, content=科普去, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Mon Dec 18 12:25:58 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270154, encodeId=45942e01549a, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 17 19:17:35 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270146, encodeId=1d7c2e01465b, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Dec 17 19:05:43 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270143, encodeId=dc982e0143cd, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 17 18:57:23 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-17 Y—xianghai

    学习了新知识

    0

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    2017-12-17 天涯183

    非常好的文章.学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2009572, encodeId=70a220095e2d6, content=<a href='/topic/show?id=f63239e24eb' target=_blank style='color:#2F92EE;'>#呼吸道症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39724, encryptionId=f63239e24eb, topicName=呼吸道症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fca128, createdName=licz0423, createdTime=Thu Mar 15 20:39:00 CST 2018, time=2018-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270820, encodeId=faa52e082049, content=有意思,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Wed Dec 20 07:26:07 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270554, encodeId=87572e0554bd, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Dec 19 09:30:54 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282436, encodeId=309e1282436a2, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Tue Dec 19 08:39:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270488, encodeId=28a92e0488ba, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Dec 19 06:47:49 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270343, encodeId=94da2e03435b, content=科普去, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Mon Dec 18 12:25:58 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270154, encodeId=45942e01549a, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 17 19:17:35 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270146, encodeId=1d7c2e01465b, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Dec 17 19:05:43 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270143, encodeId=dc982e0143cd, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 17 18:57:23 CST 2017, time=2017-12-17, status=1, ipAttribution=)]
    2017-12-17 131****1460

    学习了受益匪浅

    0