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Sci Rep：早期骨骼肌丢失是转移性肾细胞癌的预后生物标记

2017-08-17 AlexYang MedSci原创

肾细胞癌骨骼肌丢失预后标记
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骨骼肌消耗在患有晚期癌症的病人中是一种常见的现象，并且也许与不良的治疗结果相关。最近，研究人员为了调查是否骨骼肌在患有转移性肾细胞癌（mRCC）且接受靶向治疗病人中的变化与临床结果有关，利用来自许多之前进行的随机临床试验进行了一项观察性群体研究，这些试验在复旦大学上海癌症中心进行。肌肉质量通过比较在治疗开始时和治疗3-4个月后计算机断层扫描图像获得的图像来进行评估。研究总共包括了101名病人。研究

骨骼肌消耗在患有晚期癌症的病人中是一种常见的现象，并且也许与不良的治疗结果相关。最近，研究人员为了调查是否骨骼肌在患有转移性肾细胞癌（mRCC）且接受靶向治疗病人中的变化与临床结果有关，利用来自许多之前进行的随机临床试验进行了一项观察性群体研究，这些试验在复旦大学上海癌症中心进行。肌肉质量通过比较在治疗开始时和治疗3-4个月后计算机断层扫描图像获得的图像来进行评估。研究总共包括了101名病人。研究发现，在靶向治疗3-4个月后，平均骨骼肌面积从41.6cm2/m2 减少到了39.9cm2/m2 。在多变量分析中，调整了基线协变量后，肌肉损失不小于5%时在无进展（hazard ratio [HR]： 1.744， 95% confidence interval [CI]： 1.077-2.826， P=0.024）和总生存率（HR： 2.367， 95%CI： 1.253-4.469， P=0.008）展现出了显著的预后意义。另外，肌肉损失变量增加到Heng模型中显著的改善了它的区分能力。总之，早期骨骼肌损失在mRCC病人中是经常观察到的并且可以添加预后信息到目前的临床风险评分中。原始出处

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    2017-10-04 qingting

    #细胞癌#

    0

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    2017-08-19 ms1065684921169360

    #骨骼肌#

    0

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    2017-08-19 12498fa0m11暂无昵称

    #生物标记#

    0

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    2017-08-19 1249842em09(暂无昵称)

    #转移性#

    0

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    2017-08-19 zhangyxzsh

    #转移性肾细胞癌#

    0

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Sci Rep：较低的平均血小板体积可以预测肾细胞癌不良预后

之前的研究发现，改变的的平均血小板体积（MPV）在几种恶性肿瘤中存在。值得注意的是，MPV在肾细胞癌（RCC）中预后评估的价值还没有达成共识。最近，有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析，并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。研

Eur Uro：端粒长度相关的遗传变异与肾细胞癌风险增加有关。

在以往的一些研究中，外周血白细胞的相对端粒长度被认为是肾细胞癌（RCC）风险的潜在生物标志物。为了确定这种关系，研究者进行了更深入的研究。

JCO：Nivolumab联合ipilimumab——转移性肾细胞癌患者的新福音？

如今越来越多的研究表明与单一疗法相比，联合免疫抑制剂的联合疗法表现出更强的抗肿瘤活性，如黑色素瘤的治疗。开放、平行对照、剂量递增、 I 期阶段的CheckMate研究评估了nivolumab加ipilimumab联合治疗、nivolumab加酪氨酸激酶抑制剂在转移性肾细胞癌中（mRCC）的安全性和疗效。nivolumab联合ipilimumab治疗的安全性和有效性如下文所示。

Oncogene：PDZK-1可以通过抑制SHP-1的磷酸化抑制肾细胞癌的发生和发展

肾细胞癌（RCC）是最具有侵略性泌尿外科癌症之一，然而，RCC致癌作用的的机制到目前为止仍旧不清楚。最近，研究人员通过利用基因表达分析和功能聚类发现，包含PDZ结构域蛋白1（PDZK1）在人类透明细胞肾细胞癌（ccRCC）中表达下调，该现象在一些相互独立的公共ccRCC数据库中同样得到了鉴证。另外，通过在ccRCC细胞系中PDZK1的超表达和敲除，研究人员阐释了PDZK1可以抑制细胞增殖、细胞周期