J Thromb Haemost:卒中发生急性出血并发症与低涂层血小板水平相关

2015-10-29 phylis 译 MedSci原创

背景:涂层血小板是胶原蛋白和凝血酶刺激下促凝血的血小板。涂层血小板水平在非腔隙性缺血性卒中的患者中升高,在自发性脑出血的患者中降低。 目的:为了调查非腔隙性缺血性卒中患者住院期间发生急性出血是否与低涂层血小板相关。方法:检测385名非腔隙性卒中患者的涂层血小板水平。应用颅内出血或明显的颅外出血(血红蛋白下降超过2 g/dL)。 应用Cochrane-Armitage趋势检验比较不同涂层血小板的患者

背景:涂层血小板是胶原蛋白和凝血酶刺激下促凝血的血小板。涂层血小板水平在非腔隙性缺血性卒中的患者中升高,在自发性脑出血的患者中降低。

目的:为了调查非腔隙性缺血性卒中患者住院期间发生急性出血是否与低涂层血小板相关。

方法:检测385名非腔隙性卒中患者的涂层血小板水平。应用颅内出血或明显的颅外出血(血红蛋白下降超过2 g/dL)。 应用Cochrane-Armitage趋势检验比较不同涂层血小板的患者的急性出血并发症的发生。应用Logistic回归评估涂层血小板和出血并发症的相关性。

结果:15名(3.9%)患者发生了出血并发症。其中,4名为颅内出血,11名存在颅外出血。不同血小板水平,出血并发症的发生率不同:涂层血小板在前三分之一(涂层血小板< 35.5%)的患者为10.2%,涂层血小板中间三分之一为1.5%,涂层血小板在后三分之一(涂层血小板≥ 47.5%)的为0。Logistic回归分析表明涂层血小板是涂层血小板高于患者发生出血并发症的概率的14.59倍(95% CI: 3.24-65.7)。

结论:促凝血小板水平较低与非腔隙性缺血性卒中发生急性出血并发症相关。这些结果表明在卒中早期阶段,涂层血小板在对患者进行风险/获益评估中的重要作用。

原文出处:

Prodan CI, Stoner JA, Dale GL. Acute hemorrhagic complications are associated with lower coated-platelet levels in non-lacunar brain infarction. J Thromb Haemost. 2015,Oct 1.

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    2015-12-03 changfy
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    2016-10-04 丁鹏鹏

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