JAMA Dermatol:大流行期间,冻疮发病率大幅增加与 COVID-19 发病率存在弱相关性

2021-07-07 MedSci原创 MedSci原创

冻疮常见于冬季,由于气候寒冷引起的局部皮肤反复红斑、肿胀性损害,严重者可出现水疱、溃疡,病程缓慢,气候转暖后自愈,易复发。

冻疮常见于冬季,由于气候寒冷引起的局部皮肤反复红斑、肿胀性损害,严重者可出现水疱、溃疡,病程缓慢,气候转暖后自愈,易复发。2020年初,欧洲的皮肤科医生注意到与COVID-19大流行有关的冻疮急剧增加,系列报告显示,冻疮患者COVID-19检测结果呈阳性很低。与大流行相关的冻疮增加的根本原因是有争议的。

pixabay

为此,研究人员进行了一项回顾性队列研究,以评估冻疮病例的增加与COVID-19病例增加之前的关联。Kaiser Permanente Northern California 440 万人提供全面、综合的护理,所有临床信息都输入到电子病历中。医疗保健系统运营着 23 个医疗中心,为特定的城市、郊区和郊区人口中心提供服务。

研究人员比较了加利福尼亚北部2020 4 1 日至 12 31 日的 COVID-19 大流行冻疮病例和2016 4 1 日至 12 31 日的大流行前冻疮病例的年龄、性别和种族/民族特异性发病率。同时还报告了 2020 3 1 日至 11 30 诊断出的 COVID-19 病例的年龄、性别和种族/民族特异性发病率。使用 Spearman 等级相关系数测量了 207 个地点月份中冻疮发病率与 COVID-19 发病率的关联。

结果显示,在大流行期间报告的780名手足口病患者中,464名是女性(59.5%),平均年龄为36.8岁。COVID-19的发病率与207个地点月的冻疮发病率相关(Spearman系数0.18P = .01)。

大流行之前和大流行期间冻疮和 COVID-19 发病率比较

然而,在大流行期间检测的456名手足口病患者中只有17人(3.7%SARS-CoV-2呈阳性,456人中只有9人(2.0%)在手足口病诊断后6周内SARS-CoV-2呈阳性。97名患者中的1人(1.0%)的测试结果为SARS-CoV-2 IgG抗体阳性。拉美裔患者受COVID-19影响的比例过高,但没有受冻疮影响。

总之,大流行期间冻疮的发病率大幅增加,但在发现 COVID-19 病例的同一地点,冻疮的发病率并不一致。研究观察到 207 个地点月份的 COVID-19 发病率与冻疮发病率之间存在弱相关性。此外,尽管冻疮的发病率增加,但在我们的研究中,很少有冻疮患者被证实患有 COVID-19

原始出处

Patrick E. McCleskey, MD1Bree Zimmerman, MD1,2Amara Lieberman, MD1et al.Epidemiologic Analysis of Chilblains Cohorts Before and During the COVID-19 Pandemic.JAMA Dermatol. Published online June 23, 2021. doi:10.1001/jamadermatol.2021.2120

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    2021-07-08 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1837961, encodeId=1763183e961a2, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon Sep 27 10:37:07 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823729, encodeId=468c1823e29e0, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Tue Jun 21 09:37:07 CST 2022, time=2022-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997546, encodeId=dd4499e54662, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Jul 08 15:11:12 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036731, encodeId=f09b1036e31fd, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jul 08 01:37:07 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997361, encodeId=b91699e36156, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qhkeCCWcxia2oAmBPcibiaLFee2ib3Zau2E1s4cpSA3AeLFiaKM7AbNfROYJpuSEznBHeCAr78fmWwywPaiaoUM7kmqg/132, createdBy=abeb5276249, createdName=胡潇潇, createdTime=Wed Jul 07 23:33:40 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-08 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2021-07-07 胡潇潇

    学习

    0

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