JAHA:发热与ST段抬高型心梗患者预后呈显著相关

2017-07-23 MedSci MedSci原创

双相炎症反应在ST段抬高型心肌梗死(STEMI)后的心肌愈合和全身动脉粥样硬化的进展中起重要作用。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估STEMI后第一和第二炎症时相的发热对心脏远期预后影响的临床研究。本研究共纳入了550名ST段抬高型心肌梗死的患者。对纳入的研究对象测量腋下的体温,并分别测量记录第一时相(入院后3天内,max‐BT1-3d)和第二时相(入院后4-10天,max‐B

双相炎症反应在ST段抬高型心肌梗死(STEMI)后的心肌愈合和全身动脉粥样硬化的进展中起重要作用。近日,在国际心血管权威杂志JAHA上发表了一篇旨在评估STEMI后第一和第二炎症时相的发热对心脏远期预后影响的临床研究。本研究共纳入了550名ST段抬高型心肌梗死的患者。对纳入的研究对象测量腋下的体温,并分别测量记录第一时相(入院后3天内,max‐BT1-3d)和第二时相(入院后4-10天,max‐BT4-10d)的患者最高体温。之后,对患者进行长达平均5.3年的随访,随访内容主要是心脏不良事件,包括心源性死亡、急性冠脉综合征和心衰源性的再住院率。在随访期间,有80名患者经历了心脏不良事件。研究结果显示,高的max‐BT4-10d与患者远期的心脏不良事件发生呈强相关,max‐BT4-10d每升高1℃的HR为2.834,95% Cl为2.017-3.828,p<0.0001,而max‐BT1-3d与心脏不良事件的发生无显着相关性(1.136 [0.731-1.742], P=0.57)。即使将冠状动脉危险因素进行调整后,包括肾小球滤过率、梗死面积、心包积液和出院药物,第二时相的发热(m

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    2017-07-25 zhaohui6731
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    2017-07-25 gdsun
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    2017-07-25 hyf035

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