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J Dent Res：小檗碱通过调节肠道微生物群改善牙周骨质流失

2019-03-24 不详 网络

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绝经后骨质疏松症（PMO）是牙周炎的一个危险因素，目前针对PMO的治疗方法可以防止雌激素缺乏的女性牙周炎加重牙槽骨病。肠道微生物群被认为是PMO的有希望的治疗靶标。从中药材中提取的小檗碱已经通过调节肠道微生物群在肥胖和糖尿病等代谢疾病的治疗中显示出其有效性。在这里，我们假设小檗碱通过在雌激素缺乏条件下调节肠道微生物群来改善肠道屏障，从而改善牙周骨质流失。在卵巢切除（OVX）大鼠中建立实验性牙周炎动

绝经后骨质疏松症（PMO）是牙周炎的一个危险因素，目前针对PMO的治疗方法可以防止雌激素缺乏的女性牙周炎加重牙槽骨病。肠道微生物群被认为是PMO的有希望的治疗靶标。从中药材中提取的小檗碱已经通过调节肠道微生物群在肥胖和糖尿病等代谢疾病的治疗中显示出其有效性。在这里，我们假设小檗碱通过在雌激素缺乏条件下调节肠道微生物群来改善肠道屏障，从而改善牙周骨质流失。

在卵巢切除（OVX）大鼠中建立实验性牙周炎动物模型，并且在处死前用小檗碱处理OVX-牙周炎大鼠7周以进行分析。微型计算机断层扫描和组织学分析显示，与载体治疗的OVX-牙周炎大鼠相比，小檗碱治疗明显减少了OVX-牙周炎大鼠的牙槽骨损失和改善的骨代谢。与此同时，小檗碱治疗的OVX-牙周炎大鼠携带更高产量的丁酸盐产生的肠道微生物群，丁酸盐产生增加，如16S rRNA测序和高效液相色谱分析所证明。小檗碱治疗的OVX-牙周炎大鼠一直表现出改善的肠屏障完整性和肠道细胞旁通透性降低，血清内毒素水平较低。同时，与载体治疗的OVX-牙周炎大鼠相比，在小檗碱治疗的OVX-牙周炎大鼠中IL-17A相关的免疫应答减弱，其具有较低的促炎细胞因子血清水平和牙槽骨中的IL-17A +细胞减少。

总之，我们的数据表明，肠道微生物群是治疗雌激素缺乏-加重牙周骨质流失的潜在靶标，小檗碱通过调节肠道微生物群代表了一种有前景的辅助治疗。

原始出处：

Jia X, Jia L, et al., Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota. J Dent Res. 2019 Jan;98(1):107-116. doi: 10.1177/0022034518797275. Epub 2018 Sep 10.

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    2019-10-29 Boyinsh

    #骨质流失#

    0

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    2019-06-23 wjcjjian

    #微生物#

    0

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    2019-06-23 一天没事干

    很好的学习机会

    0

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    2019-06-19 一天没事干

    很好的学习机会

    0

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    2019-03-26 yangjxjc

    #肠道微生物群#

    0

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    2019-03-26 zhu_jun9837

    #微生物群#

    0

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    2019-03-26 医者仁心

    #牙周#

    0

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    2019-03-26 Eleven17

    #骨质#

    0