J Aller Cl Imm-Pract：金黄色葡萄球菌鼻腔定植与成人哮喘

2018-09-10 xing.T MedSci原创

由此可见，该研究表明鼻腔SA定植与哮喘之间存在适度但重要的关系，支持SA在成人哮喘患者中的潜在作用。进一步的纵向队列和干预研究很有必要以确定宿主决定因素并阐明相关性的因果关系。

金黄色葡萄球菌（SA）是人体中常见的定植菌，并且已知其与包括哮喘在内的慢性过敏性疾病有关。最近的个别研究表明鼻腔SA定植可能与哮喘呈正相关。近日，过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章，该研究旨在评估鼻腔SA定植与成人哮喘患病率和活动之间的关系。

研究人员检索了电子数据库的研究，截止时间至2018年6月，纳入了报告一般成人人群或慢性鼻窦炎（CRS）患者鼻腔SA定植患病率与哮喘结局（患病率和疾病活动情况）的研究，并进行随机效应荟萃分析以计算相关性的合并比值比（OR）。对CRS人群中鼻息肉的存在进行亚组分析。

该分析共确定了21项横断面研究，并对使用SA检测培养方法的16项研究的数据进行了荟萃分析（5项基于人群的普通研究和11项CRS患者研究）。在一般人群的研究中，鼻腔SA定植与哮喘患病率显著相关（OR为1.19; 95％置信区间为1.06-1.34; I2=1％）。在CRS患者研究中，也发现了类似的正相关，但具有相当大的异质性（OR为1.87; 95％CI为1.18-2.97; I2=72％）。然而，结果在具有和不具有鼻息肉的CRS患者之间是相当的。

由此可见，该研究表明鼻腔SA定植与哮喘之间存在适度但重要的关系，支持SA在成人哮喘患者中的潜在作用。进一步的纵向队列和干预研究很有必要以确定宿主决定因素并阐明相关性的因果关系。

原始出处：

Young-Chan Kim,et al. Staphylococcus aureus nasal colonization and asthma in adults: systematic review and meta-analysis. J Aller Cl Imm-Pract. 2018. https://www.jaci-inpractice.org/article/S2213-2198(18)30556-7/abstract

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2018-10-30 liuyg0228

#成人哮喘#

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2018-10-02 一个字-牛

学习了谢谢分享

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2018-09-11 jambiya

#金黄色葡萄球菌#

35 0
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2018-09-11 膀胱癌

#ALL#

29 0
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2018-09-11 mnda

#鼻腔#

38 0
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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Tue Sep 11 22:53:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344329, encodeId=75903443290c, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 10 10:08:30 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344326, encodeId=dc2534432667, content=好, beContent=null, 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2018-09-11 手留余香

#葡萄球菌#

33 0
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objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Sep 10 09:27:31 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344268, encodeId=e55b344268ab, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Mon Sep 10 08:50:37 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344265, encodeId=17fb3442652c, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Sep 10 08:18:03 CST 2018, time=2018-09-10, status=1, ipAttribution=)]
2018-09-10 明月清辉

谢谢分享，学习了

73 0
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objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Mon Sep 10 09:27:31 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344268, encodeId=e55b344268ab, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Mon Sep 10 08:50:37 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344265, encodeId=17fb3442652c, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Sep 10 08:18:03 CST 2018, time=2018-09-10, status=1, ipAttribution=)]
2018-09-10 orangesking

好

70 0
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time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305037, encodeId=9b2a130503e7c, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Tue Sep 11 22:53:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329149, encodeId=ed351329149c0, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Tue Sep 11 22:53:00 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344329, encodeId=75903443290c, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 10 10:08:30 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344326, encodeId=dc2534432667, content=好, beContent=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Sep 10 08:18:03 CST 2018, time=2018-09-10, status=1, ipAttribution=)]
2018-09-10 1e1c07bdm01(暂无匿称)

好

70 0
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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Sep 10 08:18:03 CST 2018, time=2018-09-10, status=1, ipAttribution=)]
2018-09-10 龙胆草

学习谢谢分享

71 0

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