Nat Rev Rheumatol:关节炎预防,什么方法好?

2017-05-14 枫丹白露 来宝网

通过良好的饮食和定期运动可以预防骨关节炎,“Nature Reviews风湿病学报告”中发表的一项新的专家评估报告。

通过良好的饮食和定期运动可以预防骨关节炎,“Nature Reviews风湿病学”中发表的一项新的专家评估报告。

在专家审查期间,萨里大学的研究人员确定了代谢与骨关节炎之间的关键环节。由于饮食不良和久坐不定的生活方式引起的代谢变化触发了人体和关节中细胞遗传重编程。

这种代谢变化影响细胞产生能量的能力,迫使其产生替代的功能来源。细胞上的压力导致葡萄糖过度产生,当不用于能量转化为乳酸时,葡萄糖的过量生成是难以冲洗出来的。身体中酸的异常水平导致关节软骨的炎症,阻碍运动并引起疼痛。

通过鉴定细胞中的代谢变化,有可能控制或显着减缓骨关节炎的症状,减轻数百万人的痛苦。

骨关节炎是英国最常见的关节炎形式,有875万人寻求医疗咨询。目前,对于这种痛苦的疾病没有有效的治疗方法,只有止痛药可用于治疗症状,没有已知的治疗方法。

主要作者萨里大学肌肉骨骼生理学教授Ali Mobasheri教授说:

“长久以来,骨关节炎被称为”磨损和损害疾病“,它被认为是人老化的一部分表现,但事实并非如此,我们所学到的是我们可以控制和预防这种痛苦状况的开始。

“重要的是不要低估健康饮食和生活方式的意义,不仅会影响我们的整体健康,而且可以改变导致严重的疾病的细胞,组织和器官的代谢行为。”

原始出处:

Ali Mobasheri, et al. The role of metabolism in the pathogenesis of osteoarthritis. Nature Reviews Rheumatology 13, 302–311 (2017).doi:10.1038/nrrheum.2017.50.Published online 06 April 2017

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    2017-06-28 liye789132251
  2. 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    2017-06-15 日月生辉

    认识原因,比用药还有效

    0

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    2017-05-23 骨科小医生

    改变我们的观念,尤其是生活方式

    0

  4. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue May 16 08:00:46 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-20 绛珠草小姐

    学习了,谢谢分享

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue May 16 08:00:46 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-18 大爰

    学习并分享,实用的文章!

    0

  6. 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    2017-05-17 狼毒花1982

    学习了感谢分享

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue May 16 08:00:46 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-17 tofsw

    学习了谢谢分享

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue May 16 08:00:46 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-16 lmm397
  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Tue May 16 08:00:46 CST 2017, time=2017-05-16, status=1, ipAttribution=)]
    2017-05-16 呜呜

    交流交流交流交流

    0

  10. 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    2017-05-16 七九九八

    要真正预防,还是有一定难度的

    0

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J Clin Periodontol:风湿性关节炎和牙周炎患者体内可以产生抗瓜氨酸组蛋白H3的自身抗体

这篇研究的目的是为了检测有炎症的牙周组织中是否存在瓜氨酸组蛋白的表达,以及在风湿性关节炎(RA)和牙周炎(PD)患者中检测是否存在抗瓜氨酸组蛋白的抗体。

NEJM:阿达木单抗用于儿童和青少年活动性特发性关节炎相关的葡萄膜炎

阿达木单抗可有效控制炎症并提高儿童和青少年活动性特发性关节炎相关葡萄膜炎的治疗效果

J Endod:风湿性关节炎患者罹患根尖周疏松性骨炎的流行性研究

到目前为止,还没有研究报道过风湿性关节炎(RA)与根尖周疏松性骨炎(PAR)的流行性趋势及牙髓治疗比例之间是否存在一定的联系。因此,RA对于根尖周炎的愈合以及病理生理学影响还未可知。为此,这项横向研究的目的是为了评估RA患者罹患PAR的流行性趋势以及进行根管治疗的比例与对照个体之间的差异。

J Rheumatol:早期关节炎心脏传导时间、心血管危险因素与炎症的关系

早期关节炎患者传导障碍患病率为12.5%,与普通人群相近,与炎症标志物的变化无关。然而,高胆固醇与QRS时间延长有关。

STEM CELL REP:关节炎也要有疫苗啦?

【重组干细胞对抗关节炎:旨在设计关节炎疫苗】研究人员使用基因编辑技术,重编小鼠干细胞来对抗关节炎引起的炎症以及其他慢性疾病。这些干细胞被称为智能细胞,它们会长成软骨细胞产生生物抗炎药,在理想情况下,它们可以取代关节炎软骨,同时保护由其他慢性炎症引起的组织损伤。此次研究由华盛顿大学圣路易斯医学院的研究人员和杜克大学的研究人员合作完成。首先,研究人员从小鼠的尾巴上取了一些皮肤细胞,并将它们转化为干细胞