Brain Beh Immun:益生菌是对抗抑郁症的“法宝”,12周消除抑郁症状!

2017-12-28 Heather_z727 来宝网

新的研究表明,益生菌在肠道中起作用,对大脑也有影响。奥胡斯大学的一项研究表明,它们能防止抑郁。在动物实验研究中,奥胡斯大学临床医学系的研究人员们给大鼠喂食额外的脂肪和纤维复合饲料。有些老鼠在饮用水中同时接收到一种微生物,主要是乳酸菌。只吃高脂肪食物的老鼠的行为与抑郁相似,接受益生菌强化饮用水的老鼠在行为上保持中立。换句话说,益生菌抵消不良的饮食习惯造成的后果。这项研究发表在《大脑、行为和免疫》杂志

【有益的肠道细菌可以对抗抑郁症】新的研究表明,益生菌在肠道中起作用,对大脑也有影响。奥胡斯大学的一项研究表明,它们能防止抑郁。在动物实验研究中,奥胡斯大学临床医学系的研究人员们给大鼠喂食额外的脂肪和纤维复合饲料。有些老鼠在饮用水中同时接收到一种微生物,主要是乳酸菌。只吃高脂肪食物的老鼠的行为与抑郁相似,接受益生菌强化饮用水的老鼠在行为上保持中立。换句话说,益生菌抵消不良的饮食习惯造成的后果。这项研究发表在《大脑、行为和免疫》杂志上。

在报告中,研究人员指出,未接受益生菌的大鼠脑组织中的白细胞数量增加,这可能是慢性炎症的标志,也见于超重人群和糖尿病患者的脂肪组织和肝脏。研究人员没有发现饮用水中含有益生菌的大鼠大脑中的白细胞数量增加。这可能表明一种益生菌有重组免疫系统的功能。特别是在这项研究中,大鼠在益生菌的帮助下抵消了脂肪饮食的后果。这是一个有趣的发现,它支持益生菌在肠道内起作用的结论。也为治疗抑郁症提高了新的线索。

在研究中,将大鼠分为四组组,喂饲不同的复合饲料。两组大鼠均喂额外的脂肪和纤维的饮食但是喝的水不一样,一组含有益生菌,一组则为普通的饮用水。两个对照组同时喂食高纤维和半脂肪饮食。经过12周的实验,研究人员观察到饮用益生菌的大鼠没有出现消极的症状。

研究人员解释说:“大鼠在临床上不能像人们那样忍受抑郁,他们会变得被动,无法应付紧张的情况。我们把这解释为抑郁样行为。”

这项研究表现出不健康的饮食会导致不良的身心状态,对老鼠也是如此。很难说这些结果是否可以转移给患有抑郁症的人,因为动物显然不像人类那样表现。但是研究人员认为有可能想象一些患有抑郁症的人受益于益生菌。“越来越多的研究表明,不健康的饮食有助于引发或维持抑郁。我们也知道,抑郁症患者通常生活在不健康的环境中,而与平均水平相比,可能是因为他们没有必要的资源来引导健康的生活方式。”虽然益生菌不能使食物更健康,并且不影响实验室动物的体重或血糖水平,但是益生菌仍然可以帮助减轻抑郁的症状,给病人提供改变他们生活方式的资源,所以恶性循环就会被打破。”

这项研究增加了对抑郁症和治疗方法的理解。抑郁症不应总是被认为是仅仅基于大脑中的化学失衡而发展的疾病。肠道细菌也可发挥重要作用。以这种方式,精神和躯体疾病之间的传统区别也变得更加模糊。“我们现在正在确定益生菌如何与现存的肠道细菌以及它们产生的特殊的化学化合物相互作用,这些化合物可以在我们的血液中测量,从而影响全身。这些机制的更详细的映射将有助于理解哪些患者可以从益生菌中受益,并因此如何设计未来的临床研究。”

原始出处:

Anders Abildgaard et al. Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats, Brain, Behavior, and Immunity (2017). DOI: 10.1016/j.bbi.2017.04.017.

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    2018-03-18 wangyunyb

    不错.正文还没拜读.不知要分析菌群吗

    0

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    2017-12-28 三生有幸9135

    学习一下谢谢分享

    0

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    2017-12-28 hhh678

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    2017-12-28 Y—xianghai

    学习了新知识

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