SCI REP:ABO血型与肝切除术后肝细胞癌生存率的关系分析!

2017-06-30 xing.T MedSci原创

总之,非O型血患者是肝癌肝切除术后预后不良的指标。该研究结果有助于在大型队列中进行进一步的外部验证。

ABO血型与几种恶性肿瘤的预后有关。然而,ABO血型在肝细胞癌(HCC)中的作用仍然是难以捉摸的。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员采用Cox回归分析评估了691例肝切除术后肝癌患者ABO血型的预后作用。

研究人员采用预后列线图来预测3年和5年总生存期(OS)。共有262例肝癌患者(37.9%)为O型血,199例(28.8%)患者为A型血,165例(23.9%)患者为B型血以及65例(9.4%)患者为AB型血。

研究人员发现O型血的肝癌患者中位总生存期为55个月,A型血患者为39个月,B型血患者为34个月,AB型血的患者为34个月(P=0.001,对数秩检验)。并且研究人员发现O型血患与A型血患者[风险比为1.416;95%可信区间为1.101-1.820;P=0.007]、B型血患者(风险比为 1.736;95%可信区间为1.333-2.262;P<0.001)、AB型血患者(风险比为 1.739;95%可信区间为1.210-2.499;P=0.003)和非O型血患者(风险比为1.485;95%可信区间为1.204-1.830;P<0.001)显著相关。研究人员构建的列线图(C指数为 0.687)预测预后比单独的分期更准确(C指数为0.601)。

总之,非O型血患者是肝癌肝切除术后预后不良的指标。该研究结果有助于在大型队列中进行进一步的外部验证。

原始出处:

Tao Wu,et al. ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04046-4

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    2018-01-12 changfy
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    2018-03-30 xjy02
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    2017-07-26 jyzxjiangqin

    AB0血型与肝切除术后。

    0

  6. 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    2017-07-22 1e10c84am36(暂无匿称)

    文章不错,谢谢分享

    0

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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Jul 04 20:01:02 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218424, encodeId=a09d218424bf, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jul 04 08:29:17 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218015, encodeId=eba621801543, content=ABO血型与肝病的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 03 07:30:30 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-07 jacob9231

    学习了谢谢分享

    0

  8. 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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Jul 04 20:01:02 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218424, encodeId=a09d218424bf, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jul 04 08:29:17 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218015, encodeId=eba621801543, content=ABO血型与肝病的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 03 07:30:30 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 changjiu

    谢谢,学习了

    0

  9. 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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Jul 04 20:01:02 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218424, encodeId=a09d218424bf, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jul 04 08:29:17 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218015, encodeId=eba621801543, content=ABO血型与肝病的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 03 07:30:30 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

  10. 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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Jul 04 20:01:02 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218424, encodeId=a09d218424bf, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Jul 04 08:29:17 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218015, encodeId=eba621801543, content=ABO血型与肝病的关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Jul 03 07:30:30 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 jyzxjiangqin

    ABO血型与肝病的关系。

    0

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