ATVB：他汀类药物对COVID-19相关结局的益处

2021-02-14 MedSci原创 MedSci原创

尽管他汀类药物被广泛作为降脂药用于处方，但由于他汀类药物会增加ACE2的表达，因此在新冠肺炎COVID-19流行情况下它们使用的安全性令人担忧。近日，心血管领域权威杂志Arteriosclerosis

尽管他汀类药物被广泛作为降脂药用于处方，但由于他汀类药物会增加ACE2的表达，因此在新冠肺炎 COVID-19流行情况下它们使用的安全性令人担忧。近日，心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章，这项研究旨在揭示他汀类药物与COVID-19患者60天死亡率之间的关系。

2020年1月19日至4月16日期间韩国所有经实验室检查确诊的COVID-19的患者均参加了该研究。研究人员通过总体和嵌套1：2倾向评分匹配研究评估了他汀类药物使用情况与COVID-19相关死亡率之间的关联。此外，研究人员将2019年1月至2019年6月期间韩国的COVID-19患者与回顾性队列中住院的肺炎患者的死亡风险比进行比较。

10448名COVID-19患者的中位年龄为45岁。533名（5.1％）患者服用了他汀类药物。在调整了年龄、性别和合并症之后，Cox回归显示与他汀类药物使用相关的风险比显著降低（风险比为0.637[95％CI为0.425-0.953]；P=0.0283）。此外，在比较COVID-19患者和回顾性队列中肺炎患者风险比时，使用他汀类药物具有类似的益处。

由此可见，他汀类药物使用与COVID-19患者较低的死亡率显著相关，且与肺炎患者中的结果一致。

原始出处：

Hae-Young Lee.et al.Beneficial Effect of Statins in COVID-19–Related Outcomes A National Population-Based Cohort Study.ATVB.2021.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315551

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#插入话题

插入图片

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2021-08-19 ms6390871039024434

#他汀类药#

20 0
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2021-08-15 gongliu

#TVB#

33 0
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2021-03-22 1571f5f30em

学习了

51 0
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2021-02-15 weigq

他汀真是万能药。

70 0
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2021-02-15 carrotlyl

statin plus covid

76 0
[GetPortalCommentsPageByObjectIdResponse(id=2044602, encodeId=32ac2044602e1, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Thu Aug 19 13:06:47 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977989, encodeId=278b19e798999, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun Aug 15 17:06:47 CST 2021, time=2021-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950191, encodeId=a60e9501916c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/QIX7rjwpfeQ0zhLTRicbLpqGvZ8tgwWcbic9bt4J9ZYwGpLMf33x82iap6PWacFI7FUdFaxckcPRHHdB8IOqr5Jvw/132, createdBy=b9ed2098253, createdName=1571f5f30em, createdTime=Mon Mar 22 21:31:52 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924742, encodeId=ab25924e42ea, content=他汀真是万能药。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Mon Feb 15 13:27:30 CST 2021, time=2021-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924662, encodeId=ab27924662a2, content=statin plus covid, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Mon Feb 15 07:58:54 CST 2021, time=2021-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=924564, encodeId=a1d592456471, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Sun Feb 14 13:23:02 CST 2021, time=2021-02-14, status=1, ipAttribution=)]
2021-02-14 ms2000001051330459

学习了，涨知识了！

57 0

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