Eur Respir J:采用10分钟的日间测试预测OSA患者对氧疗的反应性!

2018-01-12 xing.T MedSci原创

由此可见,觉醒状态下机械通气化学反射性检测可以被看作是一个简单的临床工具来预测OSA个体对吸氧治疗的反应。它可以为OSA的治疗提供一种新的个性化药物治疗方法。

对于阻塞性睡眠呼吸暂停(OSA)目前还没有令人满意的治疗。低流量吸氧治疗(LFO2)已被证实可减清OSA患者低氧血症,并且具有良好的耐受性。然而,吸氧疗法可能只对某些OSA患者有益。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究析文章,在这项研究中,研究人员评估了一个10分钟的清醒通气化学反射性测试在预测OSA个体对2个月LFO2治疗的反应。

在基线时,OSA患者在下午接受机械通气化学反射性测试,先于进行整夜多导睡眠图检查。受试者在夜间吸氧治疗2个月后重新进行多导睡眠检查。

在20名完成试验的OSA患者中。吸氧治疗2个月后,呼吸暂停低通气指数(AHI)的变化与基线CO2通气反应阈值(VRT)和化学敏感性显著相关(P<0.05)。在预测AHI降低方面,对于VRT的接受者操作特征曲线下面积(AUC)为0.79,而对于化学敏感性为0.89。当将这两个变量结合在一个logistic回归模型中,预测效果变得更明显,AUC为0.97,敏感性为0.92,特异性为0.83。

由此可见,觉醒状态下机械通气化学反射性检测可以被看作是一个简单的临床工具来预测OSA个体对吸氧治疗的反应。它可以为OSA的治疗提供一种新的个性化药物治疗方法。

原始出处:


David Wang,et al. Predicting response to oxygen therapy in obstructive sleep apnoea patients using a 10-minute daytime test. Eur Respir J. http://erj.ersjournals.com/content/51/1/1701587

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    2018-01-14 bioon3
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    2018-01-14 rgjl
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    2018-01-12 139****0239

    henhao

    0

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    2018-01-12 137****9095

    henhao

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2022804, encodeId=c171202280437, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Tue Dec 04 15:51:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349766, encodeId=31831349e6639, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sun Jan 14 03:51:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466542, encodeId=29d314665428f, content=<a href='/topic/show?id=621d6402097' target=_blank style='color:#2F92EE;'>#氧疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64020, encryptionId=621d6402097, topicName=氧疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8a786841989, createdName=rgjl, createdTime=Sun Jan 14 03:51:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277853, encodeId=2d4e2e7853ab, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=80d11516357, createdName=139****0239, createdTime=Fri Jan 12 14:07:06 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277839, encodeId=a4e22e7839bd, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Fri Jan 12 13:51:48 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277831, encodeId=0a8a2e783180, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Jan 12 13:16:43 CST 2018, time=2018-01-12, status=1, ipAttribution=)]
    2018-01-12 惠映实验室

    学习了.谢谢.

    0