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Diabetologia：妊娠期糖尿病妇女从妊娠晚期到产后葡萄糖代谢的纵向变化

2020-03-18 MedSci原创 MedSci原创

妊娠；糖尿病
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本研究旨在确定妊娠期糖尿病(GDM)妇女的胰岛素敏感性(松田胰岛素敏感性指数;从妊娠晚期(妊娠第34-37周，第1天)到产后早期(1-5天，第2天)和产后晚期(6-12周，第3天)。

本研究旨在确定妊娠期糖尿病(GDM)妇女的胰岛素敏感性(松田胰岛素敏感性指数;从妊娠晚期(妊娠第34-37周，第1天)到产后早期(1-5天，第2天)和产后晚期(6-12周，第3天)。次要目的是将母体脂质、脂肪因子、细胞因子和体重的纵向变化与ISOGTT、胰岛素反应和DI的变化联系起来。

研究人员利用75 g OGTT的结果计算3个时间点(T1、T2和T3)的ISOGTT、胰岛素反应和DI。在每次OGTT前测量脂肪因子、细胞因子和脂质。采用线性混合效应模型比较各个时间点的变化。评估ISOGTT、胰岛素反应和DI的变化与母体各时间点的脂肪因子、细胞因子和脂质变化相关。

研究结果显示，共有27名妇女完成了所有评估。与T1相比，ISOGTT在产后1-5天比T1高11.20 (95% CI 8.09, 14.31)个单位(p < 0.001)，在产后6-12周比T1高5.49 (95% CI 2.38, 8.60)个单位(p < 0.001)。与T1相比，T2时胰岛素响应值降低699.6 (95% CI 957.5, 441.6)个单位(p < 0.001)，T3时降低356.3 (95% CI 614.3, 98.3)个单位(p = 0.004)。与T1相比，T2时DI升高6434.1 (95% CI 2486.2, 10381.0)个单位(p = 0.001)， T3时DI升高4262.0 (95% CI 314.6, 8209.3)个单位(p = 0.03)。从T1到T2，平均胆固醇、三酰甘油、低密度脂蛋白胆固醇和vldl -胆固醇水平均下降(p < 0.001)，而c反应蛋白、IL-6和IL-8水平均升高(p < 0.001)。平均瘦素水平从T1下降到T2 (p = 0.001)。母亲的平均体重指数从T1降至T2 (p = 0.001)，从T3降至T3 (p < 0.001)。从T1到T2, ISOGTT、胰岛素反应和DI的变化与母体细胞因子、脂肪因子、脂质或体重的变化之间没有显著的相关性。

研究结果表明，对于患有GDM的女性，分娩与胰岛素敏感性和最初几天内胰岛素产量的改善相关。胰岛素分泌改善持续6-12周，但胰岛素敏感性略有下降。这些葡萄糖代谢的变化与脂质、瘦素、炎症标志物或体重的变化无关。

原始出处：

Shin Y. Kim, Andrea J. Sharma,Longitudinal changes in glucose metabolism in women with gestational diabetes, from late pregnancy to the postpartum period

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    2020-05-12 ms9608593228839890

    #DIA#

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    2020-11-29 ms5439512287675881

    #BET#

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    2020-07-12 gjsgj

    #妊娠晚期#

    0

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    2020-03-20 wjcjjian

    #妊娠期#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1639392, encodeId=98b51639392ff, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 12 22:31:45 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761346, encodeId=29b01e613468c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Nov 29 17:31:45 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744060, encodeId=94331e4406061, content=<a href='/topic/show?id=27064486ecb' target=_blank style='color:#2F92EE;'>#妊娠晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44867, encryptionId=27064486ecb, topicName=妊娠晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e935261579, createdName=gjsgj, createdTime=Sun Jul 12 11:31:45 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251244, encodeId=d26d125124495, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253660, encodeId=4f5c1253660f8, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360620, encodeId=e4c71360620b1, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553658, encodeId=2b34155365848, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043015, encodeId=30d5104301570, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 00:31:45 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-20 shenxlcyp

    #妊娠期糖尿病#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1639392, encodeId=98b51639392ff, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 12 22:31:45 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761346, encodeId=29b01e613468c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Nov 29 17:31:45 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744060, encodeId=94331e4406061, content=<a href='/topic/show?id=27064486ecb' target=_blank style='color:#2F92EE;'>#妊娠晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44867, encryptionId=27064486ecb, topicName=妊娠晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e935261579, createdName=gjsgj, createdTime=Sun Jul 12 11:31:45 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251244, encodeId=d26d125124495, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253660, encodeId=4f5c1253660f8, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360620, encodeId=e4c71360620b1, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553658, encodeId=2b34155365848, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043015, encodeId=30d5104301570, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 00:31:45 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-20 zz70

    #糖代谢#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1639392, encodeId=98b51639392ff, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 12 22:31:45 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761346, encodeId=29b01e613468c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Nov 29 17:31:45 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744060, encodeId=94331e4406061, content=<a href='/topic/show?id=27064486ecb' target=_blank style='color:#2F92EE;'>#妊娠晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44867, encryptionId=27064486ecb, topicName=妊娠晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e935261579, createdName=gjsgj, createdTime=Sun Jul 12 11:31:45 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251244, encodeId=d26d125124495, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253660, encodeId=4f5c1253660f8, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360620, encodeId=e4c71360620b1, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553658, encodeId=2b34155365848, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043015, encodeId=30d5104301570, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 00:31:45 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-20 wfang550

    #葡萄糖代谢#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1639392, encodeId=98b51639392ff, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue May 12 22:31:45 CST 2020, time=2020-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761346, encodeId=29b01e613468c, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Nov 29 17:31:45 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744060, encodeId=94331e4406061, content=<a href='/topic/show?id=27064486ecb' target=_blank style='color:#2F92EE;'>#妊娠晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44867, encryptionId=27064486ecb, topicName=妊娠晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c2e935261579, createdName=gjsgj, createdTime=Sun Jul 12 11:31:45 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251244, encodeId=d26d125124495, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253660, encodeId=4f5c1253660f8, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360620, encodeId=e4c71360620b1, content=<a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76615, encryptionId=16a6e66155b, topicName=糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30f5146, createdName=zz70, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553658, encodeId=2b34155365848, content=<a href='/topic/show?id=abae8824611' target=_blank style='color:#2F92EE;'>#葡萄糖代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88246, encryptionId=abae8824611, topicName=葡萄糖代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82e414392307, createdName=wfang550, createdTime=Fri Mar 20 12:31:45 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043015, encodeId=30d5104301570, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 00:31:45 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-19 misszhang

    谢谢MedSci提供最新的资讯

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