SCI REP:中国农村人群静息心率和脉压对2型糖尿病的独立和累积效应影响!

2017-06-02 xing.T MedSci原创

这项研究表明,升高的RHR和PP各自独立地与T2DM的风险相关,也影响了传统的混杂因素,RHR较快PP较高可能累积地增加T2DM的风险。然而,潜在的临床应用仍有待进一步明确。

近日,Scientific reports 杂志上发表了一篇研究文章,研究人员旨在通过横断面研究和荟萃分析来探讨静息心率(RHR)和脉压(PP)对2型糖尿病(T2DM)风险的独立效应以及它们的累积效应。

该研究共纳入了8276名来自于农村糖尿病、肥胖和生活方式研究(RuralDiab研究)中的年龄在35岁至74岁的受试者。同时,进行了两项荟萃分析以验证流行病学研究的结果。

研究人员发现RHR和PP与T2DM的风险增高有关,而每个四分位数相应的调整后比值比(95%可信区间)分别为1.0、0.99(0.68-1.42)、1.58(1.13-2.20)、2.93(2.15–3.98)和1、1.06(0.75-1.48)、1.11(0.79-1.56)、1.45(1.03-2.03)。累积效应分析表明相比于缓慢RHR低PP人群、男性、女性,快速RHR高PP受试者调整后的比值比(95%可信区间)在分别为3.36(2.26-4.99)、2.60(1.47-4.59)和3.60(2.09-6.20)。Meta分析结果显示RHR和PP合并效应值分别为1.94(1.64-2.31)和1.25(1.04-1.51)。

这项研究表明,升高的RHR和PP各自独立地与T2DM的风险相关,也影响了传统的混杂因素,RHR较快PP较高可能累积地增加T2DM的风险。然而,潜在的临床应用仍有待进一步明确。

原始出处:


Panpan Wang,et al. Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population. Scientific reports. 2017. https://www.nature.com/articles/s41598-017-02758-1

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1804425, encodeId=0933180442578, content=<a href='/topic/show?id=c754e7083a8' target=_blank style='color:#2F92EE;'>#累积效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77083, encryptionId=c754e7083a8, topicName=累积效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Tue Apr 17 13:57:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404998, encodeId=dc7d140499813, content=<a href='/topic/show?id=2c4a30e76c7' target=_blank style='color:#2F92EE;'>#农村#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30776, encryptionId=2c4a30e76c7, topicName=农村)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b76a2518787, createdName=daviiliu, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579023, encodeId=760615e90230a, content=<a href='/topic/show?id=3007990e6f0' target=_blank style='color:#2F92EE;'>#静息心率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99076, encryptionId=3007990e6f0, topicName=静息心率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=692416492771, createdName=12498761m61暂无昵称, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1804425, encodeId=0933180442578, content=<a href='/topic/show?id=c754e7083a8' target=_blank style='color:#2F92EE;'>#累积效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77083, encryptionId=c754e7083a8, topicName=累积效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Tue Apr 17 13:57:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404998, encodeId=dc7d140499813, content=<a href='/topic/show?id=2c4a30e76c7' target=_blank style='color:#2F92EE;'>#农村#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30776, encryptionId=2c4a30e76c7, topicName=农村)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b76a2518787, createdName=daviiliu, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579023, encodeId=760615e90230a, content=<a href='/topic/show?id=3007990e6f0' target=_blank style='color:#2F92EE;'>#静息心率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99076, encryptionId=3007990e6f0, topicName=静息心率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=692416492771, createdName=12498761m61暂无昵称, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=)]
    2017-06-04 daviiliu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1804425, encodeId=0933180442578, content=<a href='/topic/show?id=c754e7083a8' target=_blank style='color:#2F92EE;'>#累积效应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77083, encryptionId=c754e7083a8, topicName=累积效应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570c172, createdName=tigerlr98, createdTime=Tue Apr 17 13:57:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404998, encodeId=dc7d140499813, content=<a href='/topic/show?id=2c4a30e76c7' target=_blank style='color:#2F92EE;'>#农村#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30776, encryptionId=2c4a30e76c7, topicName=农村)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b76a2518787, createdName=daviiliu, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579023, encodeId=760615e90230a, content=<a href='/topic/show?id=3007990e6f0' target=_blank style='color:#2F92EE;'>#静息心率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99076, encryptionId=3007990e6f0, topicName=静息心率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=692416492771, createdName=12498761m61暂无昵称, createdTime=Sun Jun 04 00:57:00 CST 2017, time=2017-06-04, status=1, ipAttribution=)]