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Sci Transl Med：克罗恩病与帕金森病的共同之处

2018-01-15 药明康德 学术经纬

CDPD关联分析
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克罗恩病(Crohn’s disease，CD)是一种炎症性肠病，它在德裔犹太人群 (Ashkenazi Jewish) 中的发病率相对较高。

克罗恩病(Crohn’s disease，CD)是一种炎症性肠病，它在德裔犹太人群 (Ashkenazi Jewish) 中的发病率相对较高。西奈山伊坎医学院 (Icahn School of Medicine at Mount Sinai) 和耶鲁大学医学院 (Yale University School of Medicine) 的研究人员对德裔犹太人群中的2066名CD患者和3633名健康志愿者的外显子组进行了测序，并且进行了全基因组关联分析。分析结果表明在LRKK2基因上的两种突变与CD患病风险相关。有趣的是，过去的研究表明LRKK2基因与帕金森病 (Parkinson’s disease， PD) 的患病风险相关。这项研究发现的两种基因突变中一种 (N208D) 会增加CD风险，而另一种(N551K) 则会降低CD风险。在总计24570名CD患者， PD患者和健康志愿者中对LRKK2基因位点上其它变异的进一步分析发现基因变异对CD和PD风险的影响是相似的。例如激发LRKK2活性的基因变异都会增加CD和PD的患病风险，而对LRKK2活性没有影响或降低其活性的基因突变会降低CD和PD的患病风险。这一发现可能对进一步了解CD和PD的疾病机理和疗法开发有重要影响。

原始出处：

Ken Y. Hui，et al.，Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease.Sci Transl Med.10 Jan 2018：Vol. 10， Issue 423， eaai7795.

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    2018-08-17 bsmagic9140

    #TRA#

    0

  2. 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    2018-09-05 ms3025846204744509

    #Transl#

    0

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target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jan 17 09:56:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279100, encodeId=a92a2e91004b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Tue Jan 16 16:00:13 CST 2018, time=2018-01-16, status=1, ipAttribution=), 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    2018-02-14 yunger

    需要在中国人群中验证下

    0

  4. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Thu Feb 01 21:30:59 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282169, encodeId=acc828216966, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jan 26 08:50:19 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281398, encodeId=abf128139843, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Tue Jan 23 23:27:13 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279594, encodeId=dfd82e95940e, content=克罗恩病的治疗., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Jan 18 06:54:42 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608441, encodeId=014316084411d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jan 17 09:56:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279100, encodeId=a92a2e91004b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Tue Jan 16 16:00:13 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278832, encodeId=8bbf2e8832e2, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jan 15 21:37:12 CST 2018, time=2018-01-15, status=1, ipAttribution=)]
    2018-02-01 方舒

    学习

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Tue Jan 23 23:27:13 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279594, encodeId=dfd82e95940e, content=克罗恩病的治疗., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Jan 18 06:54:42 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608441, encodeId=014316084411d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jan 17 09:56:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279100, encodeId=a92a2e91004b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Tue Jan 16 16:00:13 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278832, encodeId=8bbf2e8832e2, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jan 15 21:37:12 CST 2018, time=2018-01-15, status=1, ipAttribution=)]
    2018-01-26 大爰

    学习了谢谢分享!!

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Tue Jan 23 23:27:13 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279594, encodeId=dfd82e95940e, content=克罗恩病的治疗., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Jan 18 06:54:42 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608441, encodeId=014316084411d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jan 17 09:56:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279100, encodeId=a92a2e91004b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Tue Jan 16 16:00:13 CST 2018, time=2018-01-16, status=1, ipAttribution=), 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    2018-01-23 方舒

    学习

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=278832, encodeId=8bbf2e8832e2, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jan 15 21:37:12 CST 2018, time=2018-01-15, status=1, ipAttribution=)]
    2018-01-18 jyzxjiangqin

    克罗恩病的治疗.

    0

  8. 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    2018-01-17 ms3994565386320060

    #Med#

    0

  9. 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    2018-01-16 cscdliu

    学习了.谢谢

    0

  10. 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target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Jan 17 09:56:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279100, encodeId=a92a2e91004b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Tue Jan 16 16:00:13 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278832, encodeId=8bbf2e8832e2, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jan 15 21:37:12 CST 2018, time=2018-01-15, status=1, ipAttribution=)]
    2018-01-15 thlabcde

    好资料学习了!

    0

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Gastroenterology：依据临床症状是活动性克罗恩病患者维持治疗期间更有效的英夫利昔单抗给药方法

研究认为，对于活动性克罗恩病患者，依据症状、生物标志物和血清药物浓度提高英夫利昔单抗剂量的治疗方法，较单纯的依据临床指标剂量提升方法不会增加无糖皮质激素临床缓解率