Neuroepidemiology:牙周病患者日后老年痴呆的发生风险较高

2016-09-28 MedSci MedSci原创

慢性牙周炎和牙龈炎与很多疾病具有相关性,然而,它们对老年痴呆的影响尚未阐明。该研究旨在观察慢性牙周炎和牙龈炎与老年痴呆发生风险之间的关系。 研究共纳入来自台湾国家健康保险研究数据库的2207名患者,这些患者在2000年1月1日至2000年12月31日之间刚刚被诊断为慢性牙周炎和牙龈炎,还纳入了性别和年龄相匹配的6621名对照。调整混杂因素后,使用Cox比例风险模型分析比较10年随访期间发生老

慢性牙周炎和牙龈炎与很多疾病具有相关性,然而,它们对老年痴呆的影响尚未阐明。该研究旨在观察慢性牙周炎和牙龈炎与老年痴呆发生风险之间的关系。

研究共纳入来自台湾国家健康保险研究数据库的2207名患者,这些患者在2000年1月1日至2000年12月31日之间刚刚被诊断为慢性牙周炎和牙龈炎,还纳入了性别和年龄相匹配的6621名对照。调整混杂因素后,使用Cox比例风险模型分析比较10年随访期间发生老年痴呆的风险。

结果显示,实验组中25人(1.13%)发生老年痴呆,对照组61人(0.92%)。Cox比例风险回归分析显示,实验组更可能发生老年痴呆(风险比2.085,95%置信区间1.552-4.156,p<0.001)。在调整性别、年龄、月收入、城镇化水平、地理区域和合并症之后,发生痴呆的风险比为2.54(95%置信区间为1.297-3.352,p=0.002)。

总而言之,该研究结果表明慢性牙周炎和牙龈炎患者日后老年痴呆的发生风险更高。然而,还需要更大样本量的研究来支持目前的研究结果。

原始出处:

Tzeng NS, Chung CH,et al., Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan. Neuroepidemiology. 2016 Sep 13;47(2):82-93. 
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    2016-10-12 zhixue

    还不重视口腔的看过来!

    0

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    2016-10-12 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1898695, encodeId=ae95189869510, content=<a href='/topic/show?id=1fa568e6ec' target=_blank style='color:#2F92EE;'>#epidemiology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6876, encryptionId=1fa568e6ec, topicName=epidemiology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri May 05 20:40:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=147113, encodeId=c8ad14e11328, content=还不重视口腔的看过来!, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25101619573, createdName=zhixue, createdTime=Wed Oct 12 17:20:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146383, encodeId=371514638305, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Oct 12 09:41:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=144884, encodeId=0a6714488456, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 18:34:55 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282241, encodeId=c04b128224124, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Sep 30 03:40:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450482, encodeId=6dad14504829f, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Sep 30 03:40:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137371, encodeId=00d613e371ce, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 22:02:30 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137370, encodeId=e9e913e370c4, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 22:02:20 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137071, encodeId=590a13e0717c, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Wed Sep 28 17:27:56 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
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    2016-09-28 知难而进

    继续关注!

    0

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    2016-09-28 知难而进

    谢谢分享!

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    2016-09-28 1de11f7fm56(暂无匿称)

    学习了,继续关注

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