JAHA:老年妇女的社会孤立与心衰住院的关系

2022-02-23 MedSci原创 MedSci原创

与传统的心衰风险因素无关,社会孤立的老年妇女患心衰的风险增加。

社会孤立—定义为客观缺乏或脱离社会联系、机构联系或社区参与,其与全因死亡率和心血管死亡率密切相关,尤其是在老年人群中。很少有前瞻性研究评估社会孤立在心力衰竭(HF)发病率中的作用。老年人社会孤立或缺乏社会网络联系与HF的关联尚不清楚。这种知识差距很重要,因为HF和社会孤立的风险随着年龄的增长而增加。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究评估了社会孤立是否与老年女性心衰事件相关,并将抑郁症状作为潜在的介导因素,将年龄、种族和民族作为影响因素。

这项研究纳入了来自妇女健康倡议(WHI)试验的44174名不同种族和民族的绝经后妇女,她们从基线(1993-1998年)到2018年期间接受了HF的年度评估。研究人员进行了介导分析,以评估抑郁症状作为潜在的介导因素,并进一步评估了年龄、种族和民族的调整效应。需要住院的HF事件是该研究的主要结局。社会孤立是一个基于婚姻/伴侣状况、宗教联系和社区联系的复合变量。研究人员使用CES-D(流行病学研究中心-抑郁症)评估了受试者的抑郁症状。

在中位15年的随访中,研究人员分析了36457名女性的数据,共发生了2364例(6.5%)心衰病例;2510(6.9%)名参与者被社会孤立。在针对社会人群、行为、临床和一般健康/功能进行调整后的多变量分析中;社交孤立的女性比非孤立的女性发生HF的风险更高(HR为1.23;95%CI为1.08-1.41)。在模型中添加抑郁症状并没有改变这种关联(HR为1.22;95%CI为1.07-1.40)。种族和民族和年龄都没有缓和社会孤立与心衰事件之间的关联。

由此可见,与传统的心衰风险因素无关,社会孤立的老年妇女患心衰的风险增加。

原始出处:

Crystal W. Cené.et al.Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women’s Health Initiative Study Findings.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.120.022907

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    2022-02-28 ms3000001777893761

    学习了

    0

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    2022-02-24 zhaohui6731
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    2022-02-24 ms1000000251410274

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    2022-02-24 1351fc2f66m

    学习一下

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    2022-02-23 吕晓锋

    多点关爱

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