Hypertension:妊娠期高血压与后代年轻人心血管风险

2017-02-22 xing.T MedSci原创

由此可见,所有怀孕期间有高血压母亲出生的孩子都可能会增加心血管疾病的终生风险。

妊娠期高血压疾病妇女心血管疾病的终生风险增加。近日,心血管权威杂志Hypertension上发表一篇研究文章,研究人员评估了后代年轻人及其兄弟姐妹的心血管风险状况。

来自于挪威HUNT研究(Nord-Trøndelag 健康研究)的15778名(平均年龄:29岁)参与者,包括210个兄弟姐妹群组,都可以得到挪威医学出生登记中心的信息。研究人员测定了参与者的血压、人体测量、血脂、C-反应蛋白水平。706名参与者出生前在妊娠期暴露于母体高血压:336名母亲有妊娠期高血压,343名足月产参与者母亲有先兆子痫,有27名早产参与者母亲先兆子痫。


相比于正常血压孕妇的子代,母亲有妊娠期高血压的子代个体收缩压高2.7(95%可信区间为1.8-3.5)mmHg,舒张压高1.5(0.9-2.1)mmHg,体重指数高0.66(0.31-1.01)kg/m2,以及腰围要大1.49(0.65-2.33)cm。研究人员在妊娠高血压和足月产先兆子痫患者中观察到了类似的结果。足月产先兆子痫也与较高浓度的非高密度脂蛋白胆固醇(0.14mmol/L,0.03-0.25)和甘油三酯(0.13mmol/L,0.06-0.21)有关。正常血压孕妇生出的兄弟姐妹与高血压孕妇出生的兄弟姐妹有几乎相同的危险因素水平。妊娠高血压孕妇所生的后代年轻人比正常血压孕妇生出的后代年轻人出现不良心血管风险要高。他们正常妊娠后出生的兄弟姐妹也有类似的风险,这表明共享的基因或生活方式可能解释这种相关性,而不是宫内因素的效应。

由此可见,所有怀孕期间有高血压母亲出生的孩子都可能会增加心血管疾病的终生风险。

原始出处:

Ingvild V. Alsnes, et al. Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood. Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08414

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    2017-12-19 feather89
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    2017-02-24 wjcjjian
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    2017-02-23 飛歌

    唉年纪越大风险越高啊

    0

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