DIABETOLOGIA：循环脂肪细胞脂肪酸结合蛋白水平与2型糖尿病肾结局和死亡风险的前瞻性关联

2019-04-04 不详网络

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横断面研究发现，循环脂肪细胞脂肪酸结合蛋白(AFABP)水平升高与糖尿病肾病分期有关。然而，目前尚不清楚这些较高的血清水平是否反映了AFABP在糖尿病肾病(DKD)发展中的作用，还是仅仅由于其在DKD中的肾清除功能受损。在此，我们前瞻性地研究了血清AFABP水平对2型糖尿病患者的肾脏不良预后的影响。

研究人员测量了5454名来自香港西糖尿病登记处的中国参与者基线血清AFABP水平。使用多变量Cox回归分析评估了循环AFABP水平与事件不良肾结局之间的关系。不良肾结局定义为eGFR持续下降40%、需要肾替代治疗或肾移植的终末期肾病或肾死亡的综合终点。

结果显示，在5年的中位随访中，5454名参与者中有754人出现了肾损害事件。在对DKD进展的传统危险因素进行调整后，循环AFABP水平升高与事件不良肾结局独立相关(HR 1.43, 95% CI 1.31, 1.57, p < 0.001)。重要的是，血清AFABP的预后作用与研究参与者的基线白蛋白尿状态或eGFR水平无关。

循环AFABP水平可以预测事件的肾脏不良结果，即使在基线肾功能相对完好的参与者中也是如此，这表明它可能是DKD早期风险分层的有效标志。

原始出处：

Chi Ho Lee, Chloe Y. Y. Cheung, Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes

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2019-12-28 ms9608593228839890

#DIA#

22 0
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2019-07-20 1508842480_96220437

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2019-08-21 ms5439512287675881

#BET#

31 0
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2019-04-06 quxin068

#死亡风险#

21 0
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2019-04-06 shenxlcyp

#脂肪细胞#

0 0
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2019-04-05 misszhang

谢谢MedSci提供最新的资讯

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DIABETOLOGIA：循环脂肪细胞脂肪酸结合蛋白水平与2型糖尿病肾结局和死亡风险的前瞻性关联

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