European Heart Journal-Digital Health:大规模研究表明,晚上10点到11点睡觉,对心脏健康

2021-11-10 “生物世界”公众号 “生物世界”公众号

晚上10点到11点睡觉与更低的心脏病风险有关。

工作、学习、生活中的种种压力带给我们最明显的问题就是睡眠障碍,据世界卫生组织(WHO)的统计,全球睡眠障碍率达27%,而在中国,成年人失眠发生率高达38.2%,六成以上90后觉得睡眠不足。

我们都知道,人体有一个24小时的随昼夜节律变化的生物钟,生物钟调控着我们的身心健康。之前有研究表明,睡眠不足会扰乱生物钟,对心血管健康产生不利影响。而睡得太早或睡得太晚,同样会扰乱生物钟,但这是否会影响心血管健康,目前还并不清楚。

2021年11月9日,英国Huma医疗公司的研究人员在欧洲心脏病学会(ESC)旗下期刊 European Heart Journal-Digital Health 上发表了题为:Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study 的研究论文。

这项大规模研究表明,晚上10点到11点睡觉与更低的心脏病风险有关。

该研究包括2006年-2010年期间在英国生物银行(UK Biobank)招募的88026名参与者,他们年龄在43岁-79岁之间,平均年龄为61岁,女性占58%。

研究团队通过让参与者佩戴腕戴式加速度计收集他们7天内入睡和醒来的时间,并对参与者进行了生活方式、健康状况、身体评估等调查。然后他们接受了心血管疾病的诊断,包括心脏病、心力衰竭、慢性缺血性心脏病、中风及短暂性脑缺血。

研究团队在调整了年龄、性别、睡眠时间、睡眠不规律(没有固定的入睡和醒来时间)、自我报告的睡眠类型(早起或夜猫子)、吸烟、体重指数、糖尿病、血压、血胆固醇和社会经济状况等情况后,分析了睡眠时间点与心血管疾病之间的关系。

在之后平均为5.7年的随访期间,有3172名参与者(3.6%)患上了心血管疾病。其中,睡眠时间在午夜或更晚的参与者的心血管疾病发病率最高,而在晚上10点-11点入睡的人心血管疾病发病率最低。进一步性别分析显示,女性的入睡时间与心血管风险增加的相关性更强。

具体来说,与晚上10点至11点入睡相比,在晚上12点或之后入睡的人患心血管疾病的风险高出25%,在晚上11点到12点之间入睡的风险高出12%,而在晚上10点之前入睡的人患心血管疾病的风险高出24%。

该研究的领导者 David Plans 表示,这项研究表明,人们最佳入睡时间点是相对固定的,如果产生偏差可能对健康有害,危害性最大的是在午夜12点之后入睡,这可能是因为睡得太晚,要么第二天起得太晚,减少了看到晨光的可能性,要么第二天正常起床,导致睡眠时间不够,这都会影响到生物钟。

该研究还观察到女性入睡时间点与心血管疾病之间具有更强的关联,但其中的原因尚不清楚。可能是因为内分泌系统对昼夜节律紊乱的反应存在性别差异。也可能是参与者的年龄较大,而绝经后女性的心血管风险本来就会增加,因此也可能入睡时间点与心血管疾病之间的关联并无性别差异。

最后,研究团队表示,虽然这些研究结果没有显示出因果关系,但仍然能看出入睡时间点是一个潜在的独立心血管风险因素。

2019年11月,欧洲心脏病学会(ESC)旗下期刊 Cardiovascular Research 发表了一篇题为:The contribution of sleep to social inequalities in cardiovascular disorders: a multi-cohort study 的研究论文。该研究将贫穷、睡眠不足和心血管疾病联系了起来。这项超过11万人参与的大规模研究表明,睡眠不足是穷人更容易患心脏病的重要原因。

如果这些发现在其他研究中得到进一步证实,那么睡眠时间长度和入睡时间点就可以作为一个降低心血管疾病的低成本的公共卫生目标。

原始出处:

Shahram Nikbakhtian, Angus B Reed, Bernard Dillon Obika, et al. Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study. European Heart Journal - Digital Health, ztab088.

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    2022-06-01 feather89
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    2022-06-21 shizhenshan
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    2022-08-31 venlin
  4. 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encodeId=eb0a162193459, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Fri Nov 12 10:08:57 CST 2021, time=2021-11-12, status=1, ipAttribution=)]
    2022-07-02 ylz8403
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    2021-11-12 ms6000000656440728

    这个点睡觉最幸福!

    0

  6. 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    2021-11-12 zhaojie88
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  8. 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    2021-11-12 tsing_hit
  9. 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    2021-11-12 slcumt
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