Eur J Clin Pharmacol:卒中前,应用他汀类药物可降低卒中的严重程度

2016-01-23 MedSci MedSci原创

背景:卒中是一个重要的健康问题,发病率和死亡率较高。各种危险因素和心血管药物治疗组影响卒中的发生率,但是药物应用和卒中的严重程度之间的关系尚不清楚。目标:确定卒中前心血管药物使用是否与卒中严重程度相关。方法:回顾性分析布一个数据库中的数据,1974名在鲁塞尔UZ总医院住院的疑似卒中患者。应用NHISS分数评估卒中的严重程度。第一,多变量线性回归模型包括心血管药物组。第二,获得临床可以解释的结果,所

背景:卒中是一个重要的健康问题,发病率和死亡率较高。各种危险因素和心血管药物治疗组影响卒中的发生率,但是药物应用和卒中的严重程度之间的关系尚不清楚。

目标:确定卒中前心血管药物使用是否与卒中严重程度相关。

方法:回顾性分析布一个数据库中的数据,1974名在鲁塞尔UZ总医院住院的疑似卒中患者。应用NHISS分数评估卒中的严重程度。第一,多变量线性回归模型包括心血管药物组。第二,获得临床可以解释的结果,所有保留在最终的线性回归模型的变量用来获得有序Logistic回归模型中的累积比例。

结果:在多元线性回归模型的10%α水平,血管紧张素II受体阻滞剂(ARBs),他汀类药物,和抗心律失常药与卒中的严重程度显著相关,表明这些药物对卒中严重程度可能的影响。有序Logistic回归模型中,仅卒中前他汀的应用与NHISS分数呈显著相关,校正OR值为0.740(95% CI 0.580-0.944)。

结论:他汀类药物在卒中前使用与卒中严重程度降低显著相关。卒中前其他药物的应用于卒中的严重程度无相关性。

原文出处:

Desmaele S, Cornu P, et el. Relationship between pre-stroke cardiovascular medication use and stroke severity.Eur J Clin Pharmacol. 2015 Dec 26.

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authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 23:38:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59114, encodeId=dbda59114d3, content=顶, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17201683139, createdName=1de3ce2fm24(暂无匿称), createdTime=Mon Jan 25 01:23:00 CST 2016, time=2016-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59059, encodeId=61c15905941, content=预防为主, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-08-30 jj000001
  5. 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createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
  6. 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createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-02-20 1de522f9m41(暂无匿称)

    是这么回事

    0

  7. 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encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Tue Aug 30 09:29:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044391, encodeId=84ac204439101, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sun Sep 25 10:29:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=64863, encodeId=31c46486378, 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createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 李继凯

    有效

    0

  8. 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createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 李继凯

    预防

    0

  9. 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  10. 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createdBy=00e81647535, createdName=I come, createdTime=Sun Jan 24 19:55:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-24 I come

    预防为主

    0

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