JACC:2型糖尿病患者的心超分型

2017-09-28 MedSci MedSci原创

2型糖尿病(T2DM)能影响患者的心脏结构和功能,但是高血压、肥胖或者高龄同样可以引起相似的改变。近日,在国际心血管权威杂志JACC上发表了一篇旨在通过聚类分析将T2DM患者的心脏表型与临床预后联系在一起的临床研究。本研究纳入了842例T2DM患者,并对其基础的超声心动图特点和复合终点事件(心源性死亡率和住院率)进行评估。最终,共将患者分成了3个聚类。第一类患者拥有最低的左室质量分数和二尖瓣早期流

2型糖尿病(T2DM)能影响患者的心脏结构和功能,但是高血压、肥胖或者高龄同样可以引起相似的改变。近日,在国际心血管权威杂志JACC上发表了一篇旨在通过聚类分析将T2DM患者的心脏表型与临床预后联系在一起的临床研究。本研究纳入了842例T2DM患者,并对其基础的超声心动图特点和复合终点事件(心源性死亡率和住院率)进行评估。最终,共将患者分成了3个聚类。第一类患者拥有最低的左室质量分数和二尖瓣早期流入速度与二尖瓣环舒张早期速度(E /e)比值的比值,左室射血分数最高,并且主要是肥胖或者高血压发生率最低的男性。第2类患者E /e比值最高,主要是高龄女性,并且孤立性糖尿病(不伴有肥胖和高血压)的发病率最低。第3类患者的左室质量分数和容量最高,左室射血分数最低,并且主要是男性,年龄、肥胖和高血压的发生率与第1类患者相似。经过平均67个月时间的随访,复合终点事件的发生率为10.8%(56/521),第2类(HR:2.37;95% Cl: 1.15 - 4.88)和第3类患者(HR:2.19; 95% Cl: 1.00 - 4.82)的预后相似,第1类患者的预后较好。研究结果表明,对超声心动图变量

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    2018-06-19 hbwxf
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    2017-09-28 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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