Eur radiol:烟民们注意了!早戒晚托生!肺癌筛查中利用定量CT评估戒烟对吸烟人群的影响

2017-09-24 shaosai MedSci原创

本研究旨通过纵向随访4年利用定量CT评价肺癌筛查人群中戒烟对吸烟人群的影响,并将结果发表在Eur radiol上。

本研究旨通过纵向随访4年利用定量CT评价肺癌筛查人群中戒烟对吸烟人群的影响,并将结果发表在Eur radiol上。

经过4年的随访,共有314例曾长期吸烟的受试者(ES)、404例持续吸烟者(CS)和39例在基线CT检查后2年内戒烟的受试者(RQ)。对其在基线时、第3年和第4年进行CT检查并通过密度测定软件来评价平均肺密度(MLD)和肺密度直方图的第15百分位(15TH)。

结果为,在基线时,与ES(-831±31、-947±22 HU, p<0.01-0.001)相比,主动吸烟者MLD和15TH(分别为-822±35、 -936±25 HU)较高。3年后,CS的MLD和15TH(分别为-801±29、-896±23 HU)仍旧要高于ES(分别为-808±27 、-906±20 HU, p<0.01-0.001)和RQ(分别为-813±20、-909±15 HU, p<0.05-0.001)。在第4年,定量CT参数并没有出现显着性变化。重要的是,在多变量分析中,吸烟的状态能够独立预测基线和第3年(p<0.001)MLD。

本研究表明,在定量CT检查中,主动吸烟者的肺密度要高于有曾有吸烟史的患者,随着吸烟的停止,肺密度逐渐减低,这反应了因吸烟诱导的炎症减轻。因此,在临床工作中,在对肺密度的分析是,要将患者的吸烟状态纳入考虑之中。

原始出处:

Jobst BJ, Weinheimer O, Trauth M, et al,Effect of smoking cessation on quantitative computed tomography in smokers at risk in a lung cancer screening population. Eur Radiol. 2017.DOI: 10.1007/s00330-017-5030-6

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    2017-09-28 ffffffffff

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    2017-09-27 ffffffffff

    谢谢分享谢谢分享

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    2017-09-26 桃李之乐

    学习了.早戒烟.早健康

    0

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    2017-09-26 ffffffffff

    谢谢分享谢谢分享

    0

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    2017-09-25 ffffffffff

    谢谢分享谢谢分享

    0

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    2017-09-25 135****7952平儿

    学了............

    0

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    2017-09-25 lou.minghong

    V学习了谢谢分享!

    0

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    2017-09-24 小铭的皮普

    了解了

    0

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