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Diabetologia：肠内分泌K和L细胞的作用?

2018-04-19 MedSci MedSci原创

食欲葡萄糖稳态
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肠内分泌K和L细胞是调节食欲和葡萄糖稳态的重要因子。关于它们在人类中的分布并不清楚，并且对于其在2型糖尿病中是否发生改变也是未知的。近日，国际杂志 《Diabetologia》上在线发表一项关于健康个体和2型糖尿病肠内分泌K和L细胞的作用。研究人员旨在评估肠内分泌K和L细胞的分布和相关激素原加工酶（使用免疫组织化学染色），并评估2型糖尿病患者和健康参与者整个肠道相应基因的mRNA表达。 在

肠内分泌K和L细胞是调节食欲和葡萄糖稳态的重要因子。关于它们在人类中的分布并不清楚，并且对于其在2型糖尿病中是否发生改变也是未知的。近日，国际杂志 《Diabetologia》上在线发表一项关于健康个体和2型糖尿病肠内分泌K和L细胞的作用。研究人员旨在评估肠内分泌K和L细胞的分布和相关激素原加工酶（使用免疫组织化学染色），并评估2型糖尿病患者和健康参与者整个肠道相应基因的mRNA表达。 在这项横断面研究中，研究人员对12名2型糖尿病患者和12个年龄和BMI匹配的健康人接受了上下双气囊式肠镜检查，从大约30厘米的小肠和在大肠的7个特定解剖位置进行粘膜活检。 沿肠道观察到嗜铬粒蛋白A（CgA），胰高血糖素样肽-1，葡萄糖依赖性促胰岛素多肽，肽YY，激素原转化酶（PC）1/3和PC2阳性细胞的密度显著不同。CHGA的表达在肠道中没有变化，但GCG，GIP，PYY，PCSK1和PCSK2的mRNA表达沿肠道不同。与健康参与者相比，在2型糖尿病患者的小肠中分别观察到CgA阳性和PC1/3阳性细胞计数较低。与健康受试者相比，在2型糖尿病患者结肠的GCG和PYY表达水平显著升高， GIP和PCSK1

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    2018-05-31 gwc392

    #分泌#

    0

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    2018-05-18 ms5439512287675881

    #BET#

    0

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    2018-05-28 ms9608593228839890

    #DIA#

    0

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    2018-04-19 执着追梦

    学习.谢谢分享

    0

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    2018-04-19 戒馋，懒，贪

    谢谢分享学习了

    0

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    2018-04-19 1dd8f26bm82(暂无匿称)

    好资源

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