BMC Med:多脂鱼能改善学龄前儿童认知功能?想多了

2018-04-23 吴星 环球医学

2018年3月,发表在《BMC Med》的由挪威和德国科学家进行的针对学龄前儿童的随机对照试验(FINS-KIDS),考察了多脂鱼摄入与认知功能之间的相关性。

2018年3月,发表在《BMC Med》的由挪威和德国科学家进行的针对学龄前儿童的随机对照试验(FINS-KIDS),考察了多脂鱼摄入与认知功能之间的相关性。

背景:包括多脂鱼在内的海洋资源是n-3长链多不饱和脂肪酸(n-3LC-PUFA)的重要来源,n-3LC-PUFA对脑发育非常重要。据我们所知,这是首项考察多脂鱼对学龄前儿童认知功能影响的随机对照试验(RCT)。本试验的目的为考察与肉相比,增加多脂鱼的摄入是否会改善4~6岁儿童的认知功能。

方法:这项两组RCT[鱼干预研究-KIDS(FINS-KIDS)]的232名儿童从挪威卑尔根的13个幼儿园中招募而来。儿童被随机分配到多脂鱼午餐组(鲱鱼/鲭鱼)或肉类午餐组(鸡肉/羊肉/牛肉),每周3次,为期16周。餐前和餐后都对鱼和肉进行称重,记录准确的摄入量(饮食依从性)。首要结局为干预前和干预后的认知功能[通过韦氏学前和小学生智力量表第3版(WPPSI-III)测量]和精细运动协调性[通过九孔柱测验(9-HPT)测量]。两时间点都纳入了生物样本(血液、尿液、头发)和监护者调查问卷。带有幼儿园随机截距的线性混合效应模型用于分析干预前到干预后的首要结局变量的改变。

结果:试验纳入218名儿童(鱼组105人,肉组113人)。儿童平均(标准差)摄入研究餐中的2070(978)g鱼或2675(850)g肉(p<0.0001)。鱼组的血红细胞n-3LC-PUFA显着增加。主要分析中,干预对WPPSI-III评分无影响[总原始分数的平均改变:鱼组17.7,95% 置信区间(CI)14.8~20.7)vs肉组17.8,95% CI 15.0~20.6;p=0.97]。子分析中,校正了饮食依从性后,与肉组(15.2,95% CI 12.4~18.0)相比,鱼组总原始分数表现出较高的改善(20.4,95% CI 17.5~23.3)(p=0.0060);二十二碳六烯酸调节了该影响。

结论:与肉相比,多脂鱼对学龄前儿童的认知功能无有益影响。当考虑饮食依从性时,多脂鱼对认知评分具有有益影响。

原始出处:

Jannike ?yen, Ingrid Kvestad, Lisa Kolden Midtb, et al. Fatty fish intake and cognitive function: FINS-KIDS, a randomized controlled trial in preschool children. BMC Medicine 2018 16:41, Published on: 12 March 2018.

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    2018-04-25 易水河

    学习学习学习学习

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