Crit Care:神经调节辅助通气对慢性阻塞性肺疾病急性加重期患者的气流分布和死腔的影响!

2017-06-06 xing.T MedSci原创

由此可见,在AECOPD患者增加ROI4通气分布和减少死腔上NAVA优于PSV。

神经调节辅助通气(NAVA)能改善患者呼吸机相互作用;但其对通气分布和死腔的影响仍是未知。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,该研究的目的是评估NAVA和压力支持通气(PSV)期间不同水平辅助对慢性阻塞性肺疾病急性加重期(AECOPD)患者通气分布和死亡空间的影响。

研究人员将15例进行机械通气的AECOPD患者纳入了研究。最初的PSV水平设为10cmH2O通气10 分钟。此后,呼吸机模式更改为NAVA,通气10 min,维持膈肌在PSV期间相同的电活动。此外,在NAVA和PSV每10分钟进行通气模式的切换,按照以下的顺序:PSV调为5cmH2O;NAVA为50%;PSV调为15cmH2O;以及NAVA为150%(相对于初始的NAVA支持水平)。肺通气分布是通过高度相等的前后四个节段感兴趣区域(ROI)的百分比来进行评估(ROI1到ROI4分别代表腹侧、腹中、背中,背部)。研究人员检测了受试者的血气分析、通气分布(EIT)、膈肌活动(B超)和死腔分数(PeCO2与PaCO2)。

在NAVA期间循环触发和延迟均较PSV期间要低。触发器的工作显着降低在NAVA期间,相比于PSV期间。基于超声的隔膜活动在NAVA期间较高,相比于同样支持水平的PSV期间。在NAVA期间在ROI4的通气分布明显增加(P<0.05),相比于PSV(除了支持水平的50%)。在ROI3+4中也发现了类似的结果。相比PSV相应的支持水平,NAVA可以减少死腔分数。

由此可见,在AECOPD患者增加ROI4通气分布和减少死腔上NAVA优于PSV。

原始出处:

Qin Sun,et al. Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease.Critical Care.2017. https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1714-1

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    2018-01-31 tomyang96
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    2017-06-12 131****1460

    学习了,受益匪浅。

    0

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    2017-06-06 131****1460

    学习了,受益匪浅。

    0