Journal of Child Psychology and Psychiatry:双侧钩束和左侧额枕下束白质异常可能是具有破坏性行为问题的幼儿冷酷非情感行为的早期生物标记物

2021-06-28 MedSci原创 MedSci原创

双侧UF和左侧IFOF内白质微结构的改变可能是CU行为的生物标志物,即使是非常年幼的儿童。

冷酷的非情感行为对于识别严重的行为问题(CP)模式非常重要。钩束(UF)是与CP发生有关的一个主要纤维束,它连接杏仁核和眶额皮质(OFC)。 Paulo A. Graziano等在Journal of Child Psychology and Psychiatry杂志发表研究文章,其研究目的是:(a)探索典型发育期(TD)儿童和破坏性行为障碍(DBD)儿童之间UF和其他主要纤维轨迹中白质微结构的差异;(b)探索DBD组内,这些白质束的个体差异是否与共同发生的CP和CU行为有关。 四条感兴趣的纤维束 当前研究的主要目标是在典型发育期(TD)儿童和诊断为DBD的儿童中检测UF中的白质微结构以及其他主要纤维轨迹(ILF、IFOF和扣带回)。为了最大限度地提高测量CP和CU行为的可变性,DBD组由初始诊断为ADHD的儿童组成,有或没有共病ODD/CD诊断。探讨TD儿童和DBD儿童之间白质联系的差异,以及在DBD组中,在CP和CU行为表现出足够的可变性,探讨这些脑束中白质微观结构的个体差异是否与共同发生的CP和CU行为有关,即使考虑到多动症的症状。基于先前对老年人/成年人的研究,该研究预计DBD

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    2021-11-28 wjywjy
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522476, encodeId=914415224e6b1, content=<a href='/topic/show?id=46223e39897' target=_blank style='color:#2F92EE;'>#双侧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37398, encryptionId=46223e39897, topicName=双侧)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=741b11453403, createdName=wangbingxhy, createdTime=Wed Jun 30 08:47:53 CST 2021, time=2021-06-30, status=1, ipAttribution=)]
    2021-06-30 xugc
  8. 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  9. 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  10. 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