J Hypertens:尿酸和新发代谢综合征、空腹血糖受损和糖尿病风险!

2018-03-16 xing.T MedSci原创

由此可见,SUA升高与IFG风险增加相关,在年龄处于中值以上的人群中,其也与代谢综合征和糖尿病有关。

虽然一些数据表明,血清尿酸(SUA)可预测代谢异常的发生发展,但在地中海人群中的证据并不确凿。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员从蒙扎(北意大利)居民中随机抽取性别、年龄(25-74岁)的一般人群为代表。参与率为64%。在基线和10年后,研究人员测量了受试者腰围、血压、空腹血糖、血清甘油三酯、血清高密度脂蛋白胆固醇和尿酸水平。

当评估代谢综合征的发病率时,在基线无代谢综合征的个人中进行分析(n=1192);当评估空腹血糖受损(IFG)发病率时,在基线无IFG的个体中进行分析(n=1320);当评估糖尿病发病率时,则在基线无糖尿病的患者中进行分析(n=1352)。调整混杂因素后,基线SUA每增加1个SD与新发代谢综合征的风险增加无关,但与新发IFG相关(相对危险度(RR) =1.26,95%可信区间(CI)为1.06–1.5,P=0.01)。SUA增加与新发糖尿病的风险增加29%有关,基线SUA水平最高四分位数与最低四分位数相比,风险增加两倍(RR=1.29,95%CI为0.98–1.7,P=0.07;RR=2.16,95%CI为0.95–4.88,P=0.07)。对年龄处于中位数的个体进行集中分析,显示SUA增加与新发代谢综合征、IFG和糖尿病的风险增加显著相关。

由此可见,SUA升高与IFG风险增加相关,在年龄处于中值以上的人群中,其也与代谢综合征和糖尿病有关。

原始出处:


Bombelli, Michele,et al. Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Uric_acid_and_risk_of_new_onset_metabolic.97511.aspx

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    2018-09-19 feather89
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    2018-03-18 yfjms

    学习

    0

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    2018-03-16 惠映实验室

    学习了.谢谢分享.

    0

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    2018-03-16 虈亣靌

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

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    2018-03-16 清风拂面

    谢谢分享学习

    0

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