Nature Medicine：巨噬细胞Dectin1激活促进胰腺癌和癌周免疫耐受！

2017-04-11 xing.T MedSci原创

由此可见，这些数据表明靶向Dectin1的信号对开发胰腺导管腺癌免疫治疗是一个有吸引力的治疗策略。

胰腺癌的发生发展需要免疫抑制炎症与致癌突变协同作用。然而，肿瘤免疫耐受的驱动机制目前尚不明确。近日，权威杂志Nature Medicine上发表了一篇研究文章，研究人员针对这一问题进行了研究。Dectin1是一种先天性免疫受体，其对于抗真菌免疫是至关重要的，但其在无菌性炎症和肿瘤发生中的作用尚不明确。此外，Dectin1的非病原体衍生配体的特点也还没被进行归纳。

研究人员发现在胰腺导管腺癌细胞中Dectin1高表达。此外，通过实验证实减少Dectin1可以加速小鼠胰腺导管腺癌的进展，然而，删除编码Dectin1的Clec7a基因或阻断Dectin1的下游信号可以发挥针对胰腺导管腺癌保护性效应。研究人员发现在小鼠和人类的胰腺导管腺癌细胞中Dectin1可以与凝集素半乳凝素9结合，导致耐受性巨噬细胞编程和适应性免疫抑制。在信号轴完整的宿主胰腺导管腺癌进展中是可有可无的CD4+和CD8+T细胞，在阻断Dectin1-半乳凝素9轴后，成为了重组抗肿瘤免疫的不可缺少的介质。

由此可见，这些数据表明靶向Dectin1的信号对开发胰腺导管腺癌免疫治疗是一个有吸引力的治疗策略。

原始出处：

Donnele Daley, et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.Nature medicine, 2017. http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4314.html

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2018-03-12 kalseyzl

#CIN#

33 0
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2017-06-09 liye789132251

#Nat#

26 0
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2017-08-19 gdsun

#Dectin1#

29 0
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2017-07-30 jeanqiuqiu

#DIC#

31 0
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2017-04-17 1ddf0692m34(暂无匿称)

不错，学习了

62 0
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2017-04-16 cuiyejia

谢谢分享，学习了

61 0
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2017-04-13 ms1692212821629096

#Medicine#

19 0
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2017-04-13 ms3994565386320060

#Med#

18 0
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2017-04-11 Jianghuiqin

期待进一步验证！

62 0

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