Dig Dis Sci:对非静脉曲张性上消化道出血入院的老年患者进行早期内镜检查的利弊分析

2022-03-28 MedSci原创 MedSci原创

急性非静脉曲张性上消化道出血 (acutenonvaricealuppergastrointestinalbleeding,ANVUGIB)系指屈氏韧带以上的消化道的非静脉曲张性疾患引起的出血。

非静脉曲张性上消化道出血 (NVGIB) 很常见,据报道每年住院率高达160/10000,死亡率在2%至5%之间。食管胃十二指肠镜检查(EGD)是 NVGIB 的主要治疗方法。然而,EGD 的理想时机仍然不确定,低风险患者的早期 EGD(24 小时内)已被证明有助于早期出院,从而降低资源利用率,这也导致高危患者会出现危险。年龄大于 65 岁被认为是 NVGIB 患者死亡率增加的危险因素。由于虚弱和合并症增加,老年患者在延迟内镜检查的情况下可能面临更大的失代偿风险。因此,本研究使用全面的全国住院患者数据库评估了早期内窥镜检查对诊断为 NVGIB 的老年患者的影响。

研究人员纳入了2016-2017 年全国住院患者样本中包括了所有主要接受 NVGIB 并接受 EGD 的 65 岁以上患者。在调整合并症和出血严重程度后,使用调查调整的线性和逻辑回归的治疗加权逆概率,比较了早期 EGD 与晚期 EGD 分层的临床结果。

 

在初步诊断为 NVGIB 的 625,530人中,120,835 人符合试验标准;24,830 人接受了早期 EGD。 在早期 EGD 组中,平均住院时间和总费用分别减少了 1.17 天(95%CI 1.04–1.30,P  < 0.001)和 5717.24 美元(95%CI 4034.57–7399.91,P <0.001)。早期 EGD 使死亡的比值比增加1.32(95%CI 1.06–1.64,P < 0.01)。手术或血管造影的要求没有变化。出院到护理机构或家庭健康的比率两组之间相似。

图:非静脉曲张性上消化道出血行内镜检查的危险因素

 

本项研究证实在 NVGIB 老年患者的综合队列中,早期 EGD 与住院时间和费用减少有关,但也与死亡率和医院间转移增加有关。需要进一步研究以确定对这一弱势群体的最佳管理方式。

原始出处:

Mohammed El-Dallal. Et al. Pros and Cons of Performing Early Endoscopy in Geriatric Patients Admitted with Non-variceal Upper Gastrointestinal Bleeding: Analysis of the US National Inpatient Database. Digestive Diseases and Sciences.2022.

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    2022-07-28 lujian
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    2022-12-06 fusion
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