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ACS Appl Mater Interfaces： 鉴定具有抑制结核分枝杆菌效力的环六肽天然产物

2018-06-30 MedSci MedSci原创

关注

https://www.ncbi.nlm.nih.gov/pubmed/29952200

本研究旨在鉴定具有抗结核活性的天然产品。

研究人员筛选一组约500种纯化的天然产物化合物对人病原体结核分枝杆菌具有抑制作用。 鉴定了一系列具有抗结核活性的环状六肽。其中5种类似物的抑菌活性较好，最小抑制浓度范围为2.3至8.9μM。 11个结构类似物没有明显活性（MIC>20μM），表明结构活性关系。 对抗性突变体分离株的测序未能鉴定出导致抗性表型的变化。

原始出处：

Singh SB, Odingo J, et al., Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis. BMC Res Notes. 2018 Jun 28;11(1):416. doi: 10.1186/s13104-018-3526-z.

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#插入话题
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    2018-10-09 lixiaol

    #分枝杆菌#

    0

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    2019-01-08 shanyongle

    #ACE#

    0

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    2018-07-12 夏天与十三菇凉

    #FAC#

    0

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    2018-07-02 huhuaidong387

    #结核#

    0

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    2018-07-02 yaanren

    #ACS#

    0

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    2018-07-02 zhouqu_8

    #结核分枝杆菌#

    0