Diabetic Med:代谢综合征中视网膜神经纤维层厚度降低

2017-08-29 MedSci MedSci原创

于2014年3月至2016年1月开展横断面研究。对所有受试者进行人体测量和血清学生化测量,眼科检查和光谱域光学相干断层扫描(SD-OCT)。排除眼压升高,青光眼,糖尿病性视网膜病变等眼部疾病的个体。采用T检验,卡方和一般线性模型用于分析数据。

近日,国际杂志 《Diabetic Medicine》上在线发表一项关于代谢综合征中视网膜神经纤维层厚度降低的研究,调查比较代谢综合征MetS)患者和健康对照者的视网膜神经纤维层(RNFL)厚度。

研究人员于20143月至20161月开展横断面研究。对所有受试者进行人体测量和血清学生化测量,眼科检查和光谱域光学相干断层扫描(SD-OCT)。排除眼压升高,青光眼,糖尿病性视网膜病变等眼部疾病的个体。采用T检验,卡方和一般线性模型用于分析数据。

研究总共对139名参与者的278只眼进行了调查(中位数(四分位数范围)年龄:37岁(32-43岁)]MetS组鼻中隔(107.8±19.5μm)和颞上(135.7±18.9μm)部位RNFL厚度较对照组低(114.6±22.4μmP= 0.013140.7±18.2μmP=0.027,分别)。经过对年龄,性别和检查[右(OD/左(OS]眼睛的多重校正后,MetS独立地与鼻上的RFNL厚度较低(β= 0.20P=0.009)和大脑皮质优势颞叶区(β= 0.14P=0.048)相关。在代谢异常的参与者中,RNFL的厚度明显减少了,不受年龄,性别和检查眼睛的影响。

研究结果表明MetS单独地与RNFL厚度降低有关,表明神经变性与MetS的发病机制有关。

原始出处:

R. Zarei, P. Anvari, Y. Eslami,et al. Retinal nerve fibre layer thickness is reduced in metabolic syndrome

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createdBy=c2b4297, createdName=徐岩, createdTime=Mon Nov 20 18:32:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970515, encodeId=220419e05157d, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Wed Dec 06 16:32:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018087, encodeId=d5bd201808e39, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon May 07 07:32:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269938, encodeId=fc191269938c2, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430949, encodeId=3d5c14309499e, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489749, encodeId=1b2a1489e4968, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607981, encodeId=160e160e98185, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=)]
  5. 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createdBy=c2b4297, createdName=徐岩, createdTime=Mon Nov 20 18:32:00 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970515, encodeId=220419e05157d, content=<a href='/topic/show?id=fa5d5919df' target=_blank style='color:#2F92EE;'>#Diabetic#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5919, encryptionId=fa5d5919df, topicName=Diabetic)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Wed Dec 06 16:32:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018087, encodeId=d5bd201808e39, content=<a href='/topic/show?id=8adc90e9115' target=_blank style='color:#2F92EE;'>#视网膜神经纤维层厚度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Mon May 07 07:32:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269938, encodeId=fc191269938c2, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430949, encodeId=3d5c14309499e, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489749, encodeId=1b2a1489e4968, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53f28597470, createdName=stfoxst, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607981, encodeId=160e160e98185, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=)]
    2018-02-23 amyloid
  6. [GetPortalCommentsPageByObjectIdResponse(id=1760183, encodeId=ad561e6018326, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Jun 01 01:32:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801555, encodeId=b8931801555ef, content=<a href='/topic/show?id=9cd690e860a' target=_blank style='color:#2F92EE;'>#视网膜神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90786, encryptionId=9cd690e860a, topicName=视网膜神经)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Aug 31 12:32:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489749, encodeId=1b2a1489e4968, content=<a href='/topic/show?id=5293e447259' target=_blank style='color:#2F92EE;'>#神经纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74472, encryptionId=5293e447259, topicName=神经纤维)], attachment=null, 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  7. 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    2017-08-31 zutt
  8. 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  9. 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  10. 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近日,国际杂志 《Diabetologia》上在线发表一项关于轻度糖尿病及无视网膜病变的1型糖尿病患者视网膜氧气抽提的研究。研究的目的是比较没有或轻度非增殖性糖

Diabetologia:糖尿病相关突变体胰岛素p.R46Q(GlnB22-胰岛素)的体内测量和生物学特征

影响胰岛素原生物合成和折叠的胰岛素基因中的杂合突变与从永久性新生儿糖尿病到MODY的糖尿病表型有关。这些突变的在体研究可能更好地了解胰岛素突变相关糖尿病并指出最佳治疗策略。研究人员研究了含有MODY杂合子的胰岛素突变p.R46Q(GlnB22-胰岛素)基因18岁女性,通过LC-MS测量突变体和野生型胰岛素的分泌。临床研究结合了大鼠INS-1胰岛素瘤细胞中p.R46Q-胰岛素的合成和分泌的体外研究。

JCEM:全身和局部皮质类固醇激素使用与代谢综合征和体重指数有何关系?

大家都知道全身使用皮质类固醇激素可能会导致不良的心血管代谢改变,进而导致肥胖和代谢综合征(MetS)。尽管越来越多的证据表明局部使用皮质类固醇激素对系统有相当大的影响,但在一般人群中对心血管代谢的影响尚不清楚。

Diabetologia:具有先前妊娠期糖尿病和糖尿病前期妇女的特征

研究人员调查了在高危人群,如先前妊娠期糖尿病(pGDM)的妇女中是否可以检测到2型糖尿病患者的肠降血糖素降低作用。

Diabetologia:长期糖尿病的INS C94Y转基因猪模型的中枢性水肿的视网膜病变

糖尿病视网膜病变是糖尿病的严重并发症,往往导致失明。由于糖尿病视网膜病变的病理生理学尚未完全了解,新型治疗干预措施需要测试,因此需要可靠的动物模型,以模拟糖尿病性视网膜病变的所有并发症。猪眼睛与人眼共享重要的解剖和生理相似性。以前的研究已经证明INS C94Y转基因猪发展出稳定的糖尿病表型和眼睛改变如白内障。本研究的目的是深入分析来自暴露于高血糖症超过2年的慢性糖尿病状态的INS C94Y猪的视网

JAHA:成年代谢综合征与5岁以后的健康状况呈相关性!

关于代谢综合征(MetS)患者从青少年何时开始出现尚未形成统一定论。近日,在国际心血管权威杂志JAHA上发表了一篇旨在研究年龄与儿童代谢综合征与成人代谢综合征、2型糖尿病和颈动脉内中膜厚度的关系的临床研究。本研究纳入了来自4个队列的5803名参与者,平均随访时间是22.3年。研究结果显示,从5岁开始的儿童代谢综合征和超重患成人代谢综合征的风险要高2.4倍,而2型糖尿病的风险从8岁开始增加(RR,