JBJS概念回顾:肌腱-骨界面愈合加强技术

2014-04-18 佚名 丁香园

肌腱损伤在日常生活中较为常见。损伤后部分病例可以导致较为严重的畸形和功能受限。前交叉韧带和肩袖是最为常见的软组织损伤类型。文献报道ACL损伤的年发病率在1/3000左右。目前肩袖损伤的确切发生概率尚不清楚,可能从5-30%左右。在一项尸体研究中发现,全肩袖撕裂的发生率可高达30%。 为重建患者损伤后肌腱-骨界面的组织,目前有多种可以增强肌腱-骨界面愈合的方式,Kivanc Ateso

肌腱损伤在日常生活中较为常见。损伤后部分病例可以导致较为严重的畸形和功能受限。前交叉韧带和肩袖是最为常见的软组织损伤类型。文献报道ACL损伤的年发病率在1/3000左右。目前肩袖损伤的确切发生概率尚不清楚,可能从5-30%左右。在一项尸体研究中发现,全肩袖撕裂的发生率可高达30%。【原文下载】


为重建患者损伤后肌腱-骨界面的组织,目前有多种可以增强肌腱-骨界面愈合的方式,Kivanc Atesok等人对现阶段肌腱-骨界面愈合增强技术进行了总结,发表在JBJS上,其文章内容要点包括:

1)肌腱-骨界面愈合对肌腱修复后的功能恢复非常重要。

2)如何使肌腱-骨界面愈合后达到和原结构相类似的功能和生物力学作用是目前临床上的难点,因肌腱-骨界面再生的能力较差。

3)目前骨科基础研究可以增强肌腱-骨界面愈合的的技术包括:使用骨诱导生长因子类物质,富含血小板的血浆,基因治疗,骨周膜移植包被技术,骨传导拆料,细胞基础疗法,生物降解支架,仿生物贴片。

4)低强度超声脉冲和体外冲击波治疗通过刺激肌腱止点部位生物级联反应可以影响肌腱-骨界面的愈合。

5)不同负重方案和制动时间通过改变接触界面的生物动力学的性状可以影响肌腱-骨附着界面修复后的应力作用。

6)其他的处置措施,如涂料缝线,螺钉,可通过多种固定方式将生物力学因子投递到特定部位。

7)后期需要I级证据的体外或动物研究进一步明确肌腱-骨愈合的机制,并将上述研究结果应用与临床中。

原始出处:

Kivanc Atesok, MD, MSc1; Freddie H. Fu, MD, DSc, DPs2; Megan R. Wolf, BS2; Mitsuo Ochi, MD, PhD3; Laith M. Jazrawi, MD1; M. Nedim Doral, MD4; James H. Lubowitz, MD5; Scott A. Rodeo, MD6.Augmentation of Tendon-to-Bone Healing.J Bone Joint Surg Am, 2014 Mar 19;96(6):513-521. doi: 10.2106/JBJS.M.00009 【原文下载】

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    2014-06-30 huaqiang0721

    很不错的文章

    0

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    2014-05-04 z0810411329

    怎样获得更多积分

    0

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    2014-04-20 丁鹏鹏
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    2014-04-20 qingrejiedu