BMJ:血压增高是外周动脉疾病的危险因素

2015-10-02 MedSci MedSci原创

近期Emdin CA等人对420万名成年人进行了一项队列研究,探究血压与外周动脉疾病的关系,以及外周动脉疾病与其他类型血管疾病的风险间联系。研究者根据英国1990-2013年电子医疗记录里检索相关信息,纳入研究对象年龄在30-90岁,共计4 222 459名,并且有≥1年的血压监测管理记录。研究者以第一次诊断新发病外周动脉疾病的时间,以及第一次诊断其他不同类型血管疾病时间作为研究终点或观察指标。研

近期Emdin CA等人对420万名成年人进行了一项队列研究,探究血压与外周动脉疾病的关系,以及外周动脉疾病与其他类型血管疾病的风险间联系。

研究者根据英国1990-2013年电子医疗记录里检索相关信息,纳入研究对象年龄在30-90岁,共计4 222 459名,并且有≥1年的血压监测管理记录。研究者以第一次诊断新发病外周动脉疾病的时间,以及第一次诊断其他不同类型血管疾病时间作为研究终点或观察指标。

研究结果显示,当血压比正常的高20 mm Hg时,研究对象患外周动脉疾病风险增加63%(HR 1.63, 95% CI 1.59 to 1.66);不过随着研究对象的年龄与BMI增加,血压与外周动脉疾病风险间关系强度降低,但该联系不会被性别与吸烟状态所改变,即是说两者间关系与性别与吸烟状态无关。

研究者还发现外周动脉疾病会导致以下血管疾病事件风险增加,:缺血性心脏病(HR 1.68, 95% CI 1.58 to 1.79)、心力衰竭(HR 1.63, 95% CI 1.52 to 1.75)、主动脉瘤(HR 2.10, 95% CI 1.79 to 2.45)、慢性肾脏疾病(HR 1.31, 95% CI 1.25 to 1.38);不过暂未发现外周动脉疾病与出血性卒中间有何联系。与外周动脉疾病相关的血管疾病时间中,最常见的首发疾病是慢性肾脏疾病(24.4%),随后为缺血性心脏病(18.5%)、心力衰竭(14.7%)、心房颤动(13.2%)。

研究结果表明,血压增高是外周动脉疾病的一个强有力的危险因素,另外临床医生应该意识到,外周动脉疾病会导致一些列其他血管时间风险增加,包括慢性肾脏疾病、缺血性心脏病、心力衰竭、房颤和中风。

原始出处:


Emdin CA, Anderson SG, Callender T, Conrad N, Salimi-Khorshidi G, Mohseni H, et al. Usual blood pressure, peripheral arterial disease, and vascular risk: cohort study of 4.2 million adults. Bmj. 2015;351:h4865.

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    2016-05-30 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1847716, encodeId=0d84184e7166d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 30 00:53:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39183, encodeId=f29939183fa, content=我们国家何时也有这么大样本的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Sun Oct 18 21:34:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37831, encodeId=24d33e83162, content=高血压导致动脉粥样硬化, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9daf1619121, createdName=Keren1970, createdTime=Wed Oct 07 10:56:00 CST 2015, time=2015-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561572, encodeId=c47215615e2af, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567581, encodeId=4145156e58157, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593260, encodeId=4dfd1593260fe, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37643, encodeId=8a653e6431c, content=一个大型的真实世界研究,结论还是非常靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Oct 03 10:05:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2015-10-18 zhouxue1990

    我们国家何时也有这么大样本的研究

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1847716, encodeId=0d84184e7166d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 30 00:53:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39183, encodeId=f29939183fa, content=我们国家何时也有这么大样本的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Sun Oct 18 21:34:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37831, encodeId=24d33e83162, content=高血压导致动脉粥样硬化, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9daf1619121, createdName=Keren1970, createdTime=Wed Oct 07 10:56:00 CST 2015, time=2015-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561572, encodeId=c47215615e2af, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567581, encodeId=4145156e58157, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593260, encodeId=4dfd1593260fe, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37643, encodeId=8a653e6431c, content=一个大型的真实世界研究,结论还是非常靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Oct 03 10:05:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2015-10-07 Keren1970

    高血压导致动脉粥样硬化

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1847716, encodeId=0d84184e7166d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 30 00:53:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=39183, encodeId=f29939183fa, content=我们国家何时也有这么大样本的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Sun Oct 18 21:34:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37831, encodeId=24d33e83162, content=高血压导致动脉粥样硬化, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9daf1619121, createdName=Keren1970, createdTime=Wed Oct 07 10:56:00 CST 2015, time=2015-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561572, encodeId=c47215615e2af, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567581, encodeId=4145156e58157, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593260, encodeId=4dfd1593260fe, content=<a href='/topic/show?id=8d1342e95fa' target=_blank style='color:#2F92EE;'>#外周动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42795, encryptionId=8d1342e95fa, topicName=外周动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b27818121614, createdName=wujh_7312825, createdTime=Sun Oct 04 02:53:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37643, encodeId=8a653e6431c, content=一个大型的真实世界研究,结论还是非常靠谱, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sat Oct 03 10:05:00 CST 2015, time=2015-10-03, status=1, ipAttribution=)]
    2015-10-04 liuxiaona
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    2015-10-04 liuxiaona
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    2015-10-03 medcardio

    一个大型的真实世界研究,结论还是非常靠谱

    0

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