SCI REP:POAG患者采用他氟前列素治疗后旁中心凹毛细血管视网膜血流速度改变!

2017-07-11 xing.T MedSci原创

由此可见,这些结果表明他氟前列素不仅可以降低眼内压,也可以改善原发性开角型青光眼患者视网膜循环,并且AOSLO可能有助于评估治疗后视网膜循环的变化。

虽然视网膜和视盘的眼部循环与青光眼的病理机制有关,但直接测量的血流速度却很难获得。

近日,Scientific reports 杂志上发表了一篇研究文章,该前瞻性研究纳入了11例未接受治疗的原发性开角型青光眼(POAG)患者和11名健康受试者,并且使用多种方式评估在原发性开角型青光眼患者接受局部他氟前列素治疗后在基线和治疗后1周、4周和12周对眼部循环的影响,研究人员采用的这些评估方式包括适应性光学激光扫描眼底镜检查(AOSLO)。

研究人员发现相比于健康眼睛,原发性开角型青光眼基线平均眼内压(IOP)显著升高,平均旁中央凹血流速度(pBFV)明显降低。此外,研究人员还发现从基线至开始治疗后随访期间平均眼内压(1周为-19.1%;4周为-17.7%;12周为-23.5%;P均<0.001)和平均pBFV显著增加(1周为14.9%,P=0.007;4周为21.3%,P<0.001;12周为14.3%,P=0.002)明显下降 。

由此可见,这些结果表明他氟前列素不仅可以降低眼内压,也可以改善原发性开角型青光眼患者视网膜循环,并且AOSLO可能有助于评估治疗后视网膜循环的变化。

原始出处:


Yuto Iida, Tadamichi Akagi,et al. Retinal Blood Flow Velocity Change in Parafoveal Capillary after Topical Tafluprost Treatment in Eyes with Primary Open-angle Glaucoma.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-05258-4

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    2017-07-13 zutt
  5. [GetPortalCommentsPageByObjectIdResponse(id=1694846, encodeId=129816948468f, content=<a href='/topic/show?id=a48a63e0086' target=_blank style='color:#2F92EE;'>#毛细血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63700, encryptionId=a48a63e0086, topicName=毛细血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ab329781157, createdName=wshxjq, createdTime=Tue Jun 19 08:01:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1812152, encodeId=41e6181215214, content=<a href='/topic/show?id=71a5891e8ee' target=_blank style='color:#2F92EE;'>#血流速度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89178, encryptionId=71a5891e8ee, topicName=血流速度)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Tue Dec 19 09:01:00 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801613, encodeId=e2ef1801613c5, content=<a href='/topic/show?id=570b9081641' target=_blank style='color:#2F92EE;'>#视网膜血流速度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90816, encryptionId=570b9081641, topicName=视网膜血流速度)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Sun Apr 15 09:01:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269906, encodeId=f47612699069b, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Jul 13 04:01:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221389, encodeId=ffce22138906, content=学习过了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Jul 12 11:04:01 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221329, encodeId=93f722132923, content=学了。。。。。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Jul 12 07:52:07 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221055, encodeId=76f7221055a8, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Tue Jul 11 13:12:09 CST 2017, time=2017-07-11, status=1, ipAttribution=)]
    2017-07-12 明天会更好!

    学习过了,谢谢分享!

    0

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    2017-07-12 135****7952平儿

    学了。。。。。。。。。。。

    0

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    2017-07-11 楠博One

    学习谢谢分享

    0