Diabetes care:1型糖尿病降脂治疗有助于降低心血管风险?

2016-05-26 MedSci MedSci原创

心血管事件是导致1型糖尿病患者死亡的主要原因。本文评估了1型糖尿病患者降脂治疗(LLT)对于预防心血管疾病的作用。研究人员采用瑞典国家糖尿病登记(NDR)进行倾向指数–基础研究。降脂治疗的倾向指数来自于32个临床和社会经济变量。倾向指数用于评估降脂治疗的作用。我们采用Cox回归对降脂治疗和未降脂治疗患者的急性心肌梗死、中风、冠心病、心血管和全因死亡的风险进行评估。研究人员纳入了2006-2008年

心血管事件是导致1型糖尿病患者死亡的主要原因。本文评估了1型糖尿病患者降脂治疗(LLT)对于预防心血管疾病的作用。

研究人员采用瑞典国家糖尿病登记(NDR)进行倾向指数–基础研究。降脂治疗的倾向指数来自于32个临床和社会经济变量。倾向指数用于评估降脂治疗的作用。我们采用Cox回归对降脂治疗和未降脂治疗患者的急性心肌梗死、中风、冠心病、心血管和全因死亡的风险进行评估。研究人员纳入了2006-2008年NDR中截止2012年12月31日无心血管疾病病史的1型糖尿病患者共24230例,18843例未予以降脂治疗、5387例予以降脂治疗。平均随访年限为6年。

研究结果显示,倾向指数在有/无降脂治疗的患者中无统计学差异。降脂治疗与无降脂治疗的危险比(HR)如下:心血管死亡0.60(95% CI 0.50–0.72),全因死亡0.56(95% CI 0.48-0.64),致死性/非致死性中风0.56(95% CI 0.46-0.70),致死性/非致死性急性心梗0.78(95% CI 0.66-0.92),致死性/非致死性冠心病0.85(95% CI 0.74-0.97),致死性/非致死性心血管疾病0.77(95% CI 0.69-0.87)。

这项研究表明,降脂治疗可以使既往无心血管病史的1型糖尿病患者的心血管风险和心血管死亡减低22-44%,强调了降脂治疗减少1型糖尿病心血管风险的重要性。

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    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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