Lancet Child&Adolescent Health:超声对寨卡病毒感染导致的胎儿脑部畸形的诊断意义。

2017-06-15 qinqiyun MedSci原创

寨卡病毒(Zika)由蚊虫传播,是一种新型的导致大脑异常的致畸机制,可使婴儿患“小头症”。产前诊断和判断胎儿预后都有很大的挑战,对于大多数先天性感染的诊断都依赖于超声。

背景:寨卡病毒(Zika)由蚊虫传播,是一种新型的导致大脑异常的致畸机制,可使婴儿患“小头症”。产前诊断和判断胎儿预后都有很大的挑战,对于大多数先天性感染诊断都依赖于超声。

目的:探究适合寨卡病毒先天性感染综合征的类似方法,为临床提供早期诊断的标志以及筛查的适合时间。

方法:在寨卡病毒流行的6016年1月-11月,研究员招募早孕或中孕期实验室确诊Zika病毒感染并且胎儿超声同时异常的孕妇,超声图像是通过腹部及阴道采集。

结果:研究者分析了14例确诊寨卡病毒感染并胎儿脑部畸形的孕妇,共31张超声影像图。在妊娠的16-20周,4例(33%,总12例)胎儿超声检查提示异常。妊娠20-24周采集超声影像图的10例胎儿中有9例(90%)结果异常。妊娠24-28周的5例和妊娠满28周的4例胎儿均有严重畸形。另外有10例发生钙化,有10例伴随胼胝体畸形。此外,仅有9例(64%)超声结果提示小头畸形,说明通过超声影像来测量胎儿头围,并不是先天性寨卡病毒感染的有效筛查方法。

分析:超声检查是对于寨卡病毒暴露下妊娠的一种很好的筛查方法。公众健康应着重在妊娠22-26周时进行筛查。并且,当发现脑室扩张、皮质萎缩、钙化以及胼胝体异常时,应进一步实验室筛查寨卡病毒感染。

原始出处:
Bruno Schaub,Michele Gueneret,Eugenie Jolivet,et al.Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome:a case series.The Lancet Child&Adolescent Health.http://dx.doi.org/10.1016/S2352-4642(17)30001-9.

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    2018-03-06 docwu2019
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    2017-10-25 智慧医人
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    2018-04-30 howi
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    2017-06-17 wushaoling
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研究结果表明,中枢神经系统中的持续性病毒可能有助于与Zika病毒感染相关的神经病变的产生。虽然Zika病毒通常在人体中引起轻度病状或无症状,但可能造成儿童和成人的神经系统疾病,如果感染的孕妇将病毒传染给胎儿,可能导致严重的胎儿缺陷,如小头症。但是,作者指出,如果Zika病毒可以持续在人类的中枢神经系统和其他组织中感染,那么可能会发生除了小头症以外的,更广泛的神经系统,淋巴,免疫疾病。

Lancet Infect Dis:新加坡寨卡病毒防治经验

寨卡病毒虽然可以传播蔓延,但疾病监测,媒介控制以及社会积极参与有助于迅速遏制病毒的进一步蔓延。新加坡的防控经验将有助于其他国家应对寨卡病毒的威胁

J Virol:武汉病毒所肖庚富研究组绘制寨卡病毒感染宿主细胞的蛋白应答图谱并发现候选药物

近期,国际病毒学领域权威学术期刊《Journalof Virology》在线发表了中国科学院武汉病毒研究所肖庚富研究团队在寨卡病毒(ZIKV)感染宿主细胞的定量蛋白质组学研究中取得重要进展,研究绘制了ZIKV感染宿主细胞后宿主蛋白的调控图谱,系统展示了ZIKV与宿主蛋白的相互作用情况。相关论文题为“Quantitative proteomic analysis of mosquito C6/36

2017年4月14日Science期刊精华

图片来自Science期刊。2017年4月17日/生物谷BIOON/---本周又有一期新的Science期刊(2017年4月14日)发布,它有哪些精彩研究呢?让小编一一道来。 1.Science:先前的黄病毒感染会增强随后的寨卡病毒感染 doi:10.1126/science.aal4365 一种更加严重的登革热病毒(DENV)感染能够在之前接触过一种不同的DENV血清型的人

孕妇携带寨卡病毒,有 10% 几率生出先天性缺陷的孩子

美国疾病控制中心发布了一项新研究,详细介绍了寨卡病毒感染的孕妇的出生缺陷率,而且结果和我们担心的一样糟糕。

Nature:寨卡病毒助力蚊媒获得感染

蚊媒传染病是通过蚊虫叮咬传播给人类及动物宿主的一大类疾病。近年来,多种新发及再发病毒性蚊媒传染病,包括寨卡病毒(ZIKV)、登革病毒(DENV)和乙型脑炎病毒(JEV)等对人类的健康产生了严重的威胁。自1947年首先在乌干达发现以来,随后,ZIKV在法属波利尼西亚暴发,随即迅速蔓延至南美,引起了全球广泛关注。