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J Coll Physicians Surg Pak：口服氯喹VS口服四环素治疗皮肤利什曼病的疗效

2020-07-02 MedSci原创 MedSci原创

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本研究旨在比较口服氯喹和口服四环素在治疗皮肤利什曼病（CL）中的功效。

本研究旨在比较口服氯喹和口服四环素在治疗皮肤利什曼病（CL）中的功效。

采用介入比较研究，纳入2017年7月至2018年1月拉希姆亚汗（Rahim Yar Khan）12岁或以上的CL病例。皮肤利什曼病的诊断是根据到农村流行地区的旅行历史和未愈合的溃疡的临床特征，以及从受累部位涂片的吉姆萨染色对阿马斯蒂戈特氏菌的检测得出的。

总共随机选择了50名患者。他们分为两组。 A组用氯喹治疗，每天口服两次250毫克（10 mg / kg /天），B组用多西环素治疗，每天口服200毫克（3.3 mg / kg /天）。他们进行了三个月的随访。疗效被标记为“是”，其中完全重新上皮化或愈合，有或没有疤痕，没有硬结。

结果，A组和B组的平均年龄分别为30.56±7.14和27.96±6.97，p = 0.199。所有病例均属于农村人口，均来自流行地区。病变部位无差异。上肢是两组中最常见的病损区域，p = 0.34。 A组的有效率为100％，而B组的有效率为23（92％），p = 0.14。

综上所述，该研究结果表明，口服四环素在治疗皮肤利什曼病方面与口服氯喹一样有效。

原始出处：

Fahmida Malik 1, Malik Muhammad Hanif 1, Ghulam Mustafa. Comparing the Efficacy of Oral Chloroquine Versus Oral Tetracycline in the Treatment of Cutaneous Leishmaniasis. J Coll Physicians Surg Pak. 2019 May;29(5):403-405.doi: 10.29271/jcpsp.2019.05.403.

 

 

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    2020-08-22 qingting

    #四环素#

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2079527, encodeId=f3c820e9527ae, content=<a href='/topic/show?id=07a44046889' target=_blank style='color:#2F92EE;'>#四环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40468, encryptionId=07a44046889, topicName=四环素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Aug 22 06:34:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951240, encodeId=6973195124076, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Sun Apr 04 13:34:46 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783370, encodeId=47cc1e833708b, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sat Mar 13 05:34:46 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032563, encodeId=53b0103256384, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Jul 02 18:34:46 CST 2020, time=2020-07-02, status=1, ipAttribution=)]
    2021-04-04 jiangfeng5067

    #利什曼病#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2079527, encodeId=f3c820e9527ae, content=<a href='/topic/show?id=07a44046889' target=_blank style='color:#2F92EE;'>#四环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40468, encryptionId=07a44046889, topicName=四环素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Aug 22 06:34:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951240, encodeId=6973195124076, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Sun Apr 04 13:34:46 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783370, encodeId=47cc1e833708b, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sat Mar 13 05:34:46 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032563, encodeId=53b0103256384, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Jul 02 18:34:46 CST 2020, time=2020-07-02, status=1, ipAttribution=)]
    2021-03-13 waiwai3030

    #Coll#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2079527, encodeId=f3c820e9527ae, content=<a href='/topic/show?id=07a44046889' target=_blank style='color:#2F92EE;'>#四环素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40468, encryptionId=07a44046889, topicName=四环素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sat Aug 22 06:34:46 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951240, encodeId=6973195124076, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Sun Apr 04 13:34:46 CST 2021, time=2021-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783370, encodeId=47cc1e833708b, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sat Mar 13 05:34:46 CST 2021, time=2021-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032563, encodeId=53b0103256384, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Jul 02 18:34:46 CST 2020, time=2020-07-02, status=1, ipAttribution=)]
    2020-07-02 内科新手

    谢谢梅斯提供这么好的信息，学到很多

    0