Clin Gastroenterology H:肝硬化和急性失代偿患者门静脉血栓形成的患病率

2020-09-23 MedSci原创 MedSci原创

门静脉血栓形成(PVT)是指在门静脉主干和肝内门分支内出现的血栓,肝硬化患者的非恶性门静脉血栓形成比非肝硬化患者更为频繁。

        门静脉血栓形成(PVT)是指在门静脉主干和肝内门分支内出现的血栓,肝硬化患者的非恶性门静脉血栓形成比非肝硬化患者更为频繁。由于PVT患者通常无症状,很少出现腹部不适,通常需要发病很久后才能诊断PVT。大多数PVT患者进展缓慢且没有临床症状。但是,有些患者,尤其是急性PVT患者,会出现腹部不适或门脉高压症并发症。此外,据报道PVT可能与肝代偿失调有关,并可能影响死亡率。肝硬化患者中非恶性PVT的患病率从0.6%到23%不等。很少有研究探究PVD在急性失代偿性肝硬化患者中的患病率。此外,急性失代偿性肝硬化与PVT之间的关系仍不清楚,因此,本项研究旨在调查非恶性肝硬化和肝功能急性失代偿(AD)患者中PVT的患病率和临床意义。

 

        研究人员对2015年1月至2016年12月间对患有慢性肝病急性加重患者进行了回顾性研究(n = 2600名患者),同时也收集了从2018年7月至2019年1月的相似的患者(n = 1370名患者)。同时分析了来自2826例没有AD的肝硬化患者的PVT患病率,临床表现和危险因素的数据。

 

         研究结果显示:肝硬化和AD患者的PVT患病率为9.36%,明显高于无AD肝硬化患者5.24%)(P= .04)。在患有肝硬化和AD的患者中,最近有63.37%的患者出现PVT。与没有PVT的患者相比,PVT的患者有静脉曲张破裂出血的比例显着更高(47.33% VS 19.63%;P <.001),PVT的患者的D-二聚体中位血清水平明显更高(2.07 VS 1.25;P <.001)。脾切除和内镜下硬化治疗是肝硬化和AD患者PVT的独立危险因素。

 

         通过本项研究发现患有AD的患者中有PVT的比例明显高于没有AD的患者。PVT与静脉曲张出血增加有关,这也会增加AD的风险。

 

原始出处:

Yan Zhang. Et al. Prevalence and Clinical Significance of Portal Vein Thrombosis in Patients With Cirrhosis and Acute Decompensation.Clinical Gastroenterology and Hepatology.2020.

 

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    2021-05-09 fusion
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    2020-11-09 许安
  4. 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  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Sep 25 02:42:30 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483297, encodeId=96fe148329ef7, content=<a href='/topic/show?id=c82e991e71b' target=_blank style='color:#2F92EE;'>#静脉血栓形成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Fri Sep 25 02:42:30 CST 2020, time=2020-09-25, status=1, ipAttribution=)]
    2020-11-18 xue8602
  6. 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  7. 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    2020-11-20 zhangxiang

    0

  8. 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  9. 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World J Gastroenterology:高尔基蛋白73:一种评估肝病患者肝硬化和预后的生物标志物

肝细胞癌(HCC)是癌症相关死亡的第二大诱因,也是全球第五大最常见的癌症。

Gastroenterology:肝硬化对于孕妇及其婴儿结局的影响

有研究报道,育龄妇女的肝硬化发病率正在增加。我们都知道肝脏对于我们生命活动来说是至关重要的,肝硬化会严重影响到我们的生命活动。孕妈更是如此。

Dig Liver Dis: 新蝶呤水平升高与肝硬化患者的慢性肝功能衰竭和死亡率相关

巨噬细胞活化在肝脏和全身性炎症中起着核心作用,并参与了急慢性肝衰竭(ACLF)的发病机理。

AP&T:白细胞比例是急性肝硬化失代偿和慢性肝功能衰竭患者死亡的预测生物标志

肝硬化在全球范围内都是很严重的公共卫生问题,肝硬化导致的急性代偿失调(AD)和随后的慢性慢性肝功能衰竭(ACLF)都会导致其发病率上升。