Prostate Cancer Prostatic Dis:前列腺癌相关基因分子改变之后MRI有何变化?

2017-08-05 medsci MedSci原创

多参数磁共振成像(mpMRI)已越来越多地用于前列腺癌(PCa)的检测。最近的研究发现了PCa复发基因的不同分子亚群的改变。然而,在PCa中的分子改变与mpMRI所呈现的特性之间的关联是未知的。本研究的目的是探讨PCa中复发性分子的改变与mpMRI特征之间的关系。

多参数磁共振成像(mpMRI)已越来越多地用于前列腺癌(PCa)的检测。最近的研究发现了PCa复发基因的不同分子亚群的改变。然而,在PCa中的分子改变与mpMRI所呈现的特性之间的关联是未知的。本研究的目的是探讨PCa中复发性分子的改变与mpMRI特征之间的关系。术前对62个直径大于0.5厘米的PCa结节做了mpMRI。通过ERG基因重排、PTEN基因缺失、SPINK1过表达、SPOP基因突变和CHD1缺失分析来评估这些PCa结节。将每个PCa焦点匹配到mpMRI相应的位置上,并使用第二版前列腺影像和数据报告系统(PI-RADSv2 )通过单观察的方式对病变进行评分。在62个前列腺癌结节中,22个(35.5%)ERG基因阳性,6个(9.7%)SPINK1基因过表达,6个(9.7%)SPOP基因发生突变,4个(6.5%)CHD1缺失以及1个(1.6%)PTEN缺失。所有CHD1基因缺失的结节在mpMRI中不可见(P = 0.037);所有SPINK1基因过表达的结节在mpMRI中可见。然而,在进行统计学分析时,这些关联的统计学意义并不显著(P = 0.06)。任何分子改变与PI-RADS

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    2018-06-27 DEXTER3139
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    2017-08-07 lsndxfj
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    2017-08-07 sunylz
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    2017-08-05 1e0f8808m18(暂无匿称)

    学习了,谢谢分享。

    0

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