Oral Oncol:增强放疗对鼻咽癌后的脑干坏死发生率影响及剂量参数研究

2017-10-23 lishiting MedSci原创

这篇研究的目的是为了阐明大队列长期随访的鼻咽癌(NPC)患者经过增强放疗(IMRT)后脑干中毒的发生率以及对脑干放疗剂量的评估。

这篇研究的目的是为了阐明大队列长期随访的鼻咽癌(NPC)患者经过增强放疗(IMRT)后脑干中毒的发生率以及对脑干放疗剂量的评估。研究对2009年4月至2012年3月间在Sun Yat-sen大学癌症中心经过IMRT治疗的NPC患者进行回顾性调查。研究纳入了1544名随访超过12个月的患者,并收集其详细治疗方案数据。放疗的实施是通过同步整合升压技术设定,共进行28-33次,单次剂量为2.0-2.48 Gy。脑干坏死的界定:损伤伴随T2加权图像上的高信号强度以及T1加权图像上的低信号强度,以及治疗后MRI检测是否存在增强。结果显示,平均随访79.7个月后(范围:12.2-85.6个月),2/1544 (0.13%)的患者在12.3和18.5个月的治疗周期发展为脑干坏死。在治疗后的1, 2, 3和5年后,精算发病率分别为0.07%, 0.13%, 0.13%和0.13%。总的来说,分别有384 (24.9%), 153 (9.9%), 67 (4.3%), 39 (2.5%), 78 (5.1%)和114 (7.4%)名患者采取的过度放疗,剂量分别为Dmax≥64Gy, D1cc>59

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    2018-08-06 小几洁
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    2018-03-15 minlingfeng
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    2017-10-25 millore
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    2017-10-23 changjiu

    学习了.谢谢

    0

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