Hypertension:评估血管老化的指标你知道么?

2017-09-27 MedSci MedSci原创

血管老化(通过结构和功能评估动脉性质)是心血管风险的独立预测因素。近期,一项发表在杂志Hypertension上的研究假设了心血管危险因素的数量决定了血管老化的进展。为了对这一假设进行验证,在为期2年的2次评估中,研究者们对未确定心血管疾病的124例受试者(平均年龄51.9岁,94名男性)进行了调查。在基线时,根据受试者的危险因素数量进行(从0到2及更多)分类。研究者们评估了受试者颈动脉-股动脉脉

血管老化(通过结构和功能评估动脉性质)是心血管风险的独立预测因素。


近期,一项发表在杂志Hypertension上的研究假设了心血管危险因素的数量决定了血管老化的进展。

为了对这一假设进行验证,在为期2年的2次评估中,研究者们对未确定心血管疾病的124例受试者(平均年龄51.9岁,94名男性)进行了调查。在基线时,根据受试者的危险因素数量进行(从0到2及更多)分类。研究者们评估了受试者颈动脉-股动脉脉搏波速度,主动脉瓣增大指数,肱动脉介入扩张和颈总动脉内膜厚度,并计算其年度绝对变化。

此项研究结果显示:具有更多危险因素的受试者的脉搏波速度年平均增加更多(0个为0.09m/s/y,1个为0.152m/s/y,2个及以上为0.352m/s/y;P = 0.007)。与没有这些危险因素的患者相比,高血压和血脂异常患者的年进展率高出4倍(0.398m/s/y vs. 0.102m/s/y)。

当仅评估55岁及以下受试者时,受试者的危险因素越多,增高指数进展率越高(分别为1.15%/y vs. 1.50%/y vs. 2.99%/y,P = 0.037)。血管舒张或颈动脉内膜中层厚度的年变化之间没有发现相关性。

在普通人群中,危险因素数量的增加与脉搏波速度和增强指数等血管老化指标的加速恶化有关;相比之下,血管舒张和颈动脉内膜中层厚度对这种变化不敏感。因此,前者可能更有助于测量血管老化。

原始出处:
Terentes-Printzios D, Vlachopoulos C, et al. Cardiovascular Risk Factors Accelerate Progression of Vascular Aging in the General Population Results From the CRAVE Study (Cardiovascular Risk Factors Affecting Vascular Age). Hypertension. 2017 Sep 18. pii: HYPERTENSIONAHA.117.09633. doi: 10.1161/HYPERTENSIONAHA.117.09633. 

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    2017-09-27 忠诚向上

    好好的看一下

    0

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    2017-09-27 1e0f8808m18(暂无匿称)

    评价血管老化的指标学习了.

    0

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