JCC: 婴儿出生时脐带血中抗TNF水平对婴儿的生长发育影响甚小

2018-08-28 MedSci MedSci原创

炎症性肠病[IBD]患者的妊娠指南建议其在妊娠期间停止抗TNF的治疗,以限制胎儿暴露在其药物浓度中。虽然英夫利昔单抗[IFX]的脐带血中抗TNF浓度高于阿达木单抗[ADA],但本项目的是证明妊娠期间抗TNF治疗对于胎儿的影响不是十分明显。

背景和目标
炎症性肠病[IBD]患者的妊娠指南建议其在妊娠期间停止抗TNF的治疗,以限制胎儿暴露在其药物浓度中。虽然英夫利昔单抗[IFX]的脐带血中抗TNF浓度高于阿达木单抗[ADA],但本项目的是证明妊娠期间抗TNF治疗对于胎儿的影响不是十分明显。

方法
研究人员进行了一项前瞻性单中心队列研究,随访了怀孕期间使用IFX或ADA的IBD妇女。在疾病维持缓解的情况下,抗TNF治疗在妊娠晚期停止。出生时,测量脐带血中抗TNF浓度。使用线性回归模型以证明出生时脐带血中的抗TNF浓度。此外,本研究还收集了孕妇疾病活动,妊娠结局和婴儿1年健康结果等结果。

结果
本项研究纳入了131次怀孕[73 IFX,58 ADA]。出生时,获得了94份脐带血样本[52 IFX,42 ADA],结果显示IFX比ADA有着显着更高抗TNF水平。在妊娠晚期,IFX在胎盘上的运输呈指数增长;然而,ADA运输受到限制并以线性方式增加。总体而言,婴儿健康水平两组之间没有明显差异。

结论
我们的线性回归模型显示ADA可能在怀孕期间持续更长时间,因为胎盘上的运输低于IFX。这可以降低母亲的复发风险,而不会增加胎儿抗TNF暴露。因此推荐在怀孕期间可以使用ADA进行疾病的维持缓解治疗。

原始出处:
Shannon L Kanis. Et al. Anti-TNF Levels in Cord Blood at Birth are Associated with Anti-TNF Type. Journal of Crohn's and Colitis.2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-10-22 mfx808
  2. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-09-07 jyzxjiangqin

    婴儿出生时脐带血。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-08-30 neurowu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-08-30 snowpeakxu
  7. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1670767, encodeId=65fa16e07674f, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Mon Oct 22 23:46:00 CST 2018, time=2018-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945787, encodeId=f3cf1945e871f, content=<a href='/topic/show?id=49ce6961069' target=_blank style='color:#2F92EE;'>#生长发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69610, encryptionId=49ce6961069, topicName=生长发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun Jul 21 06:46:00 CST 2019, time=2019-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343438, encodeId=7e883434382b, content=婴儿出生时脐带血。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Sep 07 16:27:29 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347327, encodeId=dd4d134e327a1, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355160, encodeId=9dd813551602c, content=<a href='/topic/show?id=3b47846692b' target=_blank style='color:#2F92EE;'>#脐带血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84669, encryptionId=3b47846692b, topicName=脐带血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401698, encodeId=5d3214016980f, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542399, encodeId=73951542399ea, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Thu Aug 30 09:46:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341533, encodeId=836c3415339e, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Aug 28 22:45:58 CST 2018, time=2018-08-28, status=1, ipAttribution=)]
    2018-08-28 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

相关资讯

DCR:内脏脂肪面积与英夫利西单抗治疗克罗恩病粘膜愈合有关

克罗恩病中肥大的肠系膜脂肪与疾病的发生发展有很大关系,本项研究的目的是探讨克罗恩病患者内脏脂肪的面积与英夫利西单抗治疗的效果的关系。

JCC:英夫利西单抗治疗小儿克罗恩病粪便微生物特征及变化

我们已经知道克罗恩病[CD]与肠道微生物失调有关。英夫利昔单抗[IFX]也越来越多地用于治疗小儿CD,然而目前尚不清楚在IFX治疗期间肠道微生物群如何被改变。这项研究的目的是探讨儿童CD患者的粪便微生物群落组成,并评估其在IFX治疗期间的动态变化。

Dig Dis & Sci:英夫利昔单抗与阿达木单抗治疗克罗恩病的疗效比较

在克罗恩病(CD)中比较英夫利昔单抗(IFX)与阿达木单抗(ADA)的长期治疗效果的头对头研究很少。本项研究比较了IFX和ADA在CD中的短期和长期有效性和安全性。

IBD:肛瘘CD患者停用抗TNF α治疗后的结果分析

由于克罗恩病(CD)存在复发的风险而且这个概率随着时间的延长是与日俱增的,因此能否在存在肛周瘘管的CD患者中停用抗肿瘤坏死因子仍存在争议。本研究的额目的是评估抗TNFα停药后肛周和长待复发的影响。

JCC:急性重症结肠炎早期使用英夫利西单抗应答预测生物标志物的探索:一项前瞻性研究

急性重度溃疡性结肠炎[ASUC]的治疗依赖于首次和/或进一步英夫利昔单抗[IFX]的早期干预。但是使用剂量仍无有效参考。

JCC: 英夫利昔单抗的清除加速与皮质类固醇难治性急性溃疡性结肠炎患者的治疗失败有关

相当一部分患有皮质类固醇难治性急性溃疡性结肠炎[UC]的患者治疗会失败。本项研究旨在评估英夫利昔单抗[IFX]在皮质类固醇难治性急性UC患者中的药代动力学[PK],并确定诱导IFX PK与短期和长期治疗结果之间的关联。