J Vasc Interv Radiol:Child-Pugh C级肝硬化肝细胞癌自发破裂是否可行紧急经导管肝动脉栓塞?

2018-01-09 国际肝病编辑部 国际肝病

最近,J Vasc Interv Radiol杂志在线发表了我国广州中山大学第一附属医院学者的一篇文章,报道了他们使用紧急经导管肝动脉栓塞治疗Child-Pugh C级肝硬化患者因肝细胞癌自发破裂导致出血性休克的经验。

最近,J Vasc Interv Radiol杂志在线发表了我国广州中山大学第一附属医院学者的一篇文章,报道了他们使用紧急经导管肝动脉栓塞治疗Child-Pugh C级肝硬化患者因肝细胞癌自发破裂导致出血性休克的经验。

研究回顾性分析了94例患者,其中60例接受保守治疗(对照组),另外34例接受栓塞治疗。

分析显示,栓塞治疗与保守治疗相比,能更有效地稳定血液动力学状态(91.2%vs.61.7%),患者总生存率(OS)更高,30、60、120天的OS分别为73.5%vs.33.3%、52.9%vs.13.3%和29.4%vs.0。

平均随访51.07天(范围:3-237天),栓塞治疗组的中位生存时间较对照组长,特别是在休克指数介于0.6~1和休克指数≥1中、Child-Pugh得分10~11分以及合并节段或小叶门静脉癌栓的患者中(图1)。



图1.不同治疗组的中位总生存期比较

(SI:休克指数;CPC:Child-Pugh得分;PVTT:门静脉癌栓)

Child-Pugh得分12~13分,肿瘤大小≥10 cm以及门静脉癌栓是总生存预后不佳的预测因素。

作者认为,对于因肝细胞癌破裂而出现出血性休克、肝功能为Child-Pugh C级的患者,紧急行经导管肝动脉栓塞是有效的干预措施,尤其适合于休克指数≥1、Child-Pugh得分10~11分和合并一级或更低级门静脉癌栓的患者。

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topicList=[TopicDto(id=4642, encryptionId=855a464292, topicName=child)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Sun May 13 02:59:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978632, encodeId=2f8819e863232, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Mon Mar 26 04:59:00 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938778, encodeId=2ef31938e78d7, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, 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href='/topic/show?id=d6618610525' target=_blank style='color:#2F92EE;'>#自发破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86105, encryptionId=d6618610525, topicName=自发破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Thu Feb 15 04:59:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783202, encodeId=87921e8320261, content=<a href='/topic/show?id=35a3464396' target=_blank style='color:#2F92EE;'>#Child-Pugh#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4643, encryptionId=35a3464396, topicName=Child-Pugh)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Feb 02 18:59:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 05 06:59:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510117, encodeId=ae01151011e93, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Thu Jan 11 13:59:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-07-16 quxin068
  5. [GetPortalCommentsPageByObjectIdResponse(id=1973654, encodeId=2ef619e36540b, content=<a href='/topic/show?id=208d33248a1' target=_blank style='color:#2F92EE;'>#动脉栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33248, encryptionId=208d33248a1, topicName=动脉栓塞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Aug 18 13:59:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783139, encodeId=6b0d1e8313924, content=<a href='/topic/show?id=855a464292' target=_blank style='color:#2F92EE;'>#child#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, 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href='/topic/show?id=d6618610525' target=_blank style='color:#2F92EE;'>#自发破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86105, encryptionId=d6618610525, topicName=自发破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Thu Feb 15 04:59:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783202, encodeId=87921e8320261, content=<a href='/topic/show?id=35a3464396' target=_blank style='color:#2F92EE;'>#Child-Pugh#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4643, encryptionId=35a3464396, topicName=Child-Pugh)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Feb 02 18:59:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 05 06:59:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510117, encodeId=ae01151011e93, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Thu Jan 11 13:59:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-09-26 docwu2019
  6. [GetPortalCommentsPageByObjectIdResponse(id=1973654, encodeId=2ef619e36540b, content=<a href='/topic/show?id=208d33248a1' target=_blank style='color:#2F92EE;'>#动脉栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33248, encryptionId=208d33248a1, topicName=动脉栓塞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Aug 18 13:59:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783139, encodeId=6b0d1e8313924, content=<a href='/topic/show?id=855a464292' target=_blank style='color:#2F92EE;'>#child#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 05 06:59:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510117, encodeId=ae01151011e93, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Thu Jan 11 13:59:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1973654, encodeId=2ef619e36540b, content=<a href='/topic/show?id=208d33248a1' target=_blank style='color:#2F92EE;'>#动脉栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33248, encryptionId=208d33248a1, topicName=动脉栓塞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sat Aug 18 13:59:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783139, encodeId=6b0d1e8313924, content=<a href='/topic/show?id=855a464292' target=_blank style='color:#2F92EE;'>#child#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, 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href='/topic/show?id=d6618610525' target=_blank style='color:#2F92EE;'>#自发破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86105, encryptionId=d6618610525, topicName=自发破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Thu Feb 15 04:59:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783202, encodeId=87921e8320261, content=<a href='/topic/show?id=35a3464396' target=_blank style='color:#2F92EE;'>#Child-Pugh#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4643, encryptionId=35a3464396, topicName=Child-Pugh)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Feb 02 18:59:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 05 06:59:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510117, encodeId=ae01151011e93, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Thu Jan 11 13:59:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-05-29 xjy02
  9. 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  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863337, encodeId=f5ad186333e7b, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue May 29 11:59:00 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784035, encodeId=98e01e8403518, content=<a href='/topic/show?id=9cf056122f' target=_blank style='color:#2F92EE;'>#C级肝硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5612, encryptionId=9cf056122f, topicName=C级肝硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Feb 05 06:59:00 CST 2018, time=2018-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510117, encodeId=ae01151011e93, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Thu Jan 11 13:59:00 CST 2018, time=2018-01-11, status=1, ipAttribution=)]
    2018-01-11 lsj631