Hepatol Int:肝硬化患者,自发的菌血症和自发性细菌性腹膜炎有相似的临床预后

2017-12-12 MedSci MedSci原创

短期急性肾损伤和死亡率在自发性菌血症和自发性细菌性腹膜炎患者中是相似。对自发性菌血症患者的风险评估可采用基线MELD评分

自发性菌血症是肝硬化患者的一种严重感染。本研究比较了自发性细菌性腹膜炎和自发性菌血症患者的死亡率和急性肾损伤的发生率,并确定自发性菌血症患者的死亡率和急性肾损伤的危险因素。

本研究为一项回顾性研究,纳入2008年至2016年布宜诺斯艾利斯Hospital Italiano的自发性细菌性腹膜炎和自发性菌血症患者。研究比较了自发性细菌性腹膜炎和自发性菌血症两种感染导致的急性肾损伤和死亡的累积发病率,并确定自发性菌血症的危险因素。

研究结果:本研究共纳入72例自发性菌血症患者和55例自发性细菌性腹膜炎患者。大多数感染为院内感染。整体上,26%的细菌为耐药菌,11%的细菌为多重耐药菌。对末期肝病(MELD)评分进行调整,多元分析表明,急性肾损伤[亚危险比(sHR) 1.05,95%置信区间:0.67-1.63, p = 0.83)]或死亡[sHR 1.15,95%置信区间0.60-2.20, p = 0.68)]与感染类型无关。自发性菌血症患者,基线MELD评分与急性肾损伤[sHR 1.07 (95% CI 1.03-1.11, p = 0.001)]和死亡[sHR 1.07 (95% CI 1.02-1.15, p = 0.03)]独立相关。

研究结论:短期急性肾损伤和死亡率在自发性菌血症和自发性细菌性腹膜炎患者中是相似。对自发性菌血症患者的风险评估可采用基线MELD评分。

原始出处

Marciano S, Dirchwolf M, Bermudez CS, et al. Spontaneous bacteremia and spontaneous bacterial peritonitis share similar prognosis in patients with cirrhosis: a cohort study. Hepatol Int, 2017, Dec 9. doi: 10.1007/s12072-017-9837-7.

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    2017-12-14 gwc384
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    2017-12-14 sodoo
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    2017-12-14 xuyong530
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    2017-12-13 Y—xianghai

    学习了新知识

    0

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    2017-12-12 明崖

    学习了.肝硬化可能也导致免疫力低下

    0

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