BMJ:严重感染与患者压力性疾病有关

2019-11-21 不详 MedSci原创

本项旨在评估创伤和其他逆境相关严重精神病反应是否与随后威胁生命的感染风险相关。

目的:
本项旨在评估创伤和其他逆境相关严重精神病反应是否与随后威胁生命的感染风险相关。

方法:
研究人员收集了从瑞典国家数据中收集了1987年至2013年确定了与压力有关的疾病(创伤后压力障碍(PTSD),急性压力反应,适应障碍和其他压力反应)的144919个人,而诊断为与压力有关的疾病的人为为184612,同时在普通人群中匹配了1449190健康对照个体。主要结局指标是首次住院或门诊就诊,主要诊断为瑞典国家患者登记簿中具有高死亡率的严重感染(例如败血症,心内膜炎和脑膜炎或其他中枢神经系统感染),以及这些感染或感染造成的死亡。在控制了多个混杂因素之后,使用Cox模型来估计这些威胁生命的感染的危险比。

结果:
诊断为压力相关疾病的平均年龄为37岁(男性38.3%)。在平均八年的随访中,每***生命威胁感染的发生率在患有压力相关疾病的个体中为2.9,在没有压力性疾病的配对个体中为1.3。与没有诊断出与压力有关的疾病的全兄弟姐妹相比,有这种诊断的个体罹患威胁生命的感染的风险增加(危险比为1.47(95%置信区间为1.37至1.58),而PTSD为1.92(1.46至2.52))。在基于人群的分析中,与压力有关的疾病的相应估计值相似(1.58(1.51至1.65),与压力有关的疾病与威胁生命的感染有关,脑膜炎(为1.63(1.23至2.16))和心内膜炎(1.57(1.08至2.30))的相对风险最高。

结论
本项研究表明存在压力相关的疾病与随后发生威胁生命的感染风险有关。

原始出处:

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    2020-06-03 gaoxiaoe
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    2019-11-23 thm112988

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