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Diabetologia：在小鼠Ser485中卵泡刺激素通过GRK2介导的AMPK过度磷酸化增强肝糖异生

2018-07-03 MedSci MedSci原创

肝糖异生
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血清促卵泡激素（FSH）增加与空腹高血糖症相关。但是，其基本机制仍不清楚。因为过度的肝糖异生是导致高血糖症禁食的主要原因，近日，国际杂志 《Diabetologia》上在线发表一项关于在小鼠Ser485中卵泡刺激素通过GRK2介导的AMPK过度磷酸化增强肝糖异生的研究。本研究调查了FSH是否增加小鼠肝糖异生。 用低或高剂量的FSH射注用雌二醇（E2）补充持血清E2的正常水平的卵巢切除的小鼠

血清促卵泡激素（FSH）增加与空腹高血糖症相关。但是，其基本机制仍不清楚。因为过度的肝糖异生是导致高血糖症禁食的主要原因，近日，国际杂志 《Diabetologia》上在线发表一项关于在小鼠Ser485中卵泡刺激素通过GRK2介导的AMPK过度磷酸化增强肝糖异生的研究。本研究调查了FSH是否增加小鼠肝糖异生。 用低或高剂量的FSH射注用雌二醇（E2）补充持血清E2的正常水平的卵巢切除的小鼠（OVX + E2小鼠）。研究人员敲除了Crtc2，这是糖异生中的关键因子，也是Fshr以辨别他们参与FSH信号。为了评价可影响葡萄糖代谢并直接与非GPCR组分相互作用的G蛋白偶联受体（GPCR）激酶2（GRK2）的作用，使用了特异性GRK2抑制剂。检测丙酮酸耐量试验（PTT），PEPCK和葡萄糖-6-磷酸酶（G6Pase）的定量，葡糖异生的关键酶，GRK2和AMP-活化的蛋白激酶（AMPK）的磷酸化，以评估肝脏中糖异生的水平。将AMPK Ser485（AMPK S485A）的不可磷酸化突变体转染到HepG2细胞中以评估AMPK Ser485磷酸化的作用。 FSH增加空腹血糖（OVX + E2 +高剂

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    2019-05-03 马龙

    #卵泡刺激素#

    0

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    2019-01-21 ms5439512287675881

    #BET#

    0

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    2019-04-15 12498e87m50暂无昵称

    #卵泡#

    0

  4. 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likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Wed Jul 04 17:18:06 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329211, encodeId=16f0329211b4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jul 04 09:27:05 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329188, encodeId=221232918805, content=新发现.值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2019-05-29 ms1774076774505970

    #糖异生#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2018393, encodeId=e500201839345, content=<a href='/topic/show?id=8123368960e' target=_blank style='color:#2F92EE;'>#卵泡刺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36896, encryptionId=8123368960e, topicName=卵泡刺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Fri May 03 10:17:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760733, encodeId=07911e6073387, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 21 21:17:00 CST 2019, time=2019-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741216, encodeId=df171e41216a3, content=<a href='/topic/show?id=62b636895ae' target=_blank style='color:#2F92EE;'>#卵泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36895, encryptionId=62b636895ae, topicName=卵泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c3834890395, createdName=12498e87m50暂无昵称, createdTime=Mon Apr 15 13:17:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664718, encodeId=2b5f1664e1863, content=<a href='/topic/show?id=0b27e6816d0' target=_blank style='color:#2F92EE;'>#糖异生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, 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likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Wed Jul 04 17:18:06 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329211, encodeId=16f0329211b4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jul 04 09:27:05 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329188, encodeId=221232918805, content=新发现.值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2019-05-25 ms9608593228839890

    #DIA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2018393, encodeId=e500201839345, content=<a href='/topic/show?id=8123368960e' target=_blank style='color:#2F92EE;'>#卵泡刺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36896, encryptionId=8123368960e, topicName=卵泡刺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Fri May 03 10:17:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760733, encodeId=07911e6073387, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 21 21:17:00 CST 2019, time=2019-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741216, encodeId=df171e41216a3, content=<a href='/topic/show?id=62b636895ae' target=_blank style='color:#2F92EE;'>#卵泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36895, encryptionId=62b636895ae, topicName=卵泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c3834890395, createdName=12498e87m50暂无昵称, createdTime=Mon Apr 15 13:17:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664718, encodeId=2b5f1664e1863, content=<a href='/topic/show?id=0b27e6816d0' target=_blank style='color:#2F92EE;'>#糖异生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76816, encryptionId=0b27e6816d0, topicName=糖异生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=271f25816039, createdName=ms1774076774505970, createdTime=Wed May 29 06:17:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638672, encodeId=1b4916386e249, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat May 25 19:17:00 CST 2019, time=2019-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329267, encodeId=ae6c32926ed3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Wed Jul 04 17:18:06 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329211, encodeId=16f0329211b4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jul 04 09:27:05 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329188, encodeId=221232918805, content=新发现.值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-04 happsf

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2018393, encodeId=e500201839345, content=<a href='/topic/show?id=8123368960e' target=_blank style='color:#2F92EE;'>#卵泡刺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36896, encryptionId=8123368960e, topicName=卵泡刺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Fri May 03 10:17:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760733, encodeId=07911e6073387, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Wed Jul 04 17:18:06 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329211, encodeId=16f0329211b4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jul 04 09:27:05 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329188, encodeId=221232918805, content=新发现.值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-04 Y—xianghai

    学习了长知识

    0

  8. 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likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Wed Jul 04 17:18:06 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329211, encodeId=16f0329211b4, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Jul 04 09:27:05 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329188, encodeId=221232918805, content=新发现.值得深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-04 cici-moon

    新发现.值得深入研究

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2018393, encodeId=e500201839345, content=<a href='/topic/show?id=8123368960e' target=_blank style='color:#2F92EE;'>#卵泡刺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36896, encryptionId=8123368960e, topicName=卵泡刺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ba58436, createdName=马龙, createdTime=Fri May 03 10:17:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760733, encodeId=07911e6073387, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/19/89c7e7adfd96f9b7f169036850a54979.jpg, createdBy=50792079489, createdName=cici-moon, createdTime=Wed Jul 04 07:39:48 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329009, encodeId=a07d329009d4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Tue Jul 03 16:05:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328996, encodeId=0dc532899604, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 zdvfsadb

    学习了

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Tue Jul 03 15:45:39 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 wzb521zf

    一起学习学习

    0

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