SLEEP:OSAS患者的血清维生素D水平与病情明显相关

2016-02-22 QQduhp 译 MedSci原创

目标研究的目的在于评估阻塞性睡眠呼吸暂停综合症(OSAS)患者的25(OH)D水平及与OSAS严重程度、嗜睡、肺功能、夜间活动后心率和身体构成之间的关系。同时也比较相比同时患有OSAS和维生素D缺乏(VDD)的患者而言,OSAS患者体内25(OH)D的水平。 方法 这项研究在一家市中心临床睡眠医学门诊中心进行,是一项横断面研究。我们招募了近期进行夜间多导睡眠图并新确立诊断的白种人,比较他们和未患有

目标:研究的目的在于评估阻塞性睡眠呼吸暂停综合症(OSAS)患者的25(OH)D水平与OSAS严重程度、嗜睡、肺功能、夜间活动后心率和身体构成之间的关系。同时也比较相比同时患有OSAS和维生素D缺乏(VDD)的患者而言,OSAS患者体内25(OH)D的水平。 


方法:这项研究在一家市中心临床睡眠医学门诊中心进行,是一项横断面研究。我们招募了近期进行夜间多导睡眠图并新确立诊断的白种人,比较他们和未患有OSAS的民众的BMI、机体构成、颈围、嗜睡状况(通过埃普沃斯嗜睡量表进行评估)、肺功能、维生素D水平(25(OH)D)。通过使用病例对照,研究人员在控制年龄、性别、肤色、嗜睡状况、季节和BMI等因素后比较患有OSAS和未患有OSAS民众的血清25(OH)D水平。

结果:居住在柏林的106名成年人(77名男性,平均年龄为54.5岁,平均BMI为34.3kg/m2)参与研究,并将其分为未患有OSAS和轻中重度OSAS。98%的OSAS患者血清25(OH)D偏低(<75nmol/L),其中72%的患者出现了VDD(<50 nmol/L)。25(OH)D水平下降与OSAS严重程度相关(P=0.003)。25(OH)D水平与BMI、体脂百分比、AHI、夜间活动后心率负相关。 多元回归分析显示,25(OH)D水平与AHI(P= 0.016)和夜间活动后心率(P =0.0419)独立相关。单独病例对照研究显示,与未患OSAS的民众而言,OSAS患者25(OH)D水平明显降低(P=0.001)。 

结论:研究人员观察到,高加索OSAS患者普遍出现维生素D缺乏。有明显证据显示,25(OH)D与AHI和夜间活动后心率明显相关。研究人员认为:25(OH)D水平与OSAS有关。

原始出处:

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    2016-05-01 jiyangfei
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    2016-02-24 bioon3

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母乳喂养中不添加维生素D,会宝宝导致维生素D缺乏风险的增加,尤其是母乳喂养超过一年的宝宝。研究成果发表在American Journal of Public Health。多伦多圣迈克尔医院儿科的Jonathon Maguire博士说:“哺乳超过一年后的时间越长,维生素D水平越低。添加维生素D可预防的宝宝,即使哺乳时间超过1年,也不会出现维生素D缺乏。研究发现提示,应该在整个哺乳期都添加维生素D。

JAMA:孕期补充维生素D对后代3岁以内哮喘和频发喘息的作用

Augusto A. Litonjua, Vincent J. Carey, et al,Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years,JAMA,January 26, 2016http

PLoS One:儿童龋齿补充维生素D可逆转龋齿吗?

PLoS One:儿童龋齿补充维生素D可逆转龋齿吗?既往研究表明维生素D和儿童龋齿之间呈负相关,但是二者之间是否存在因果关系目前尚未清楚。本研究旨在确定循环25羟基维生素D的浓度与龋齿经历、早期龋以及牙科全麻需要之间的因果效应,早期龋和牙科麻醉的要求。采用孟德尔随机化研究,利用遗传变异,纳入5545名欧洲血统儿童,已知遗传变异与循环25羟基维生素D的浓度有关。关于龋齿及相关的特性的数据是从父母及儿

JAMA Intern Med:维生素D越多越好吗?

一项最新的研究指出,过量摄入维生素D并不会无限制地增强下肢功能,相反可能会导致老年疾病的发生。 这些结果发表在最近一期的《JAMA国际医学》杂志上,主要作者是其来自瑞士苏黎世大学的老年科主任Heike A Bischoff-Ferrari博士。在对200名最近一年来至少有过一次无创伤疾病70岁左右的男性与女性进行随机检测后,发现他们每月的维生素D3摄入量比正常摄入量(24000单位)高两倍。