Crit Care Med:哪些因素影响社区获得性脓毒症患者在院死亡率

2017-06-16 梁舒瑶 环球医学资讯

脓毒症首次医疗接触至抗菌药治疗的延迟是否影响在院死亡率?2017年5月,发表在《Crit Care Med》的一项回顾性队列研究调查了社区获得性脓毒症患者总医疗接触、院前和急诊部抗菌药延迟与在院死亡率之间的相关性。

脓毒症首次医疗接触至抗菌药治疗的延迟是否影响在院死亡率?2017年5月,发表在《Crit Care Med》的一项回顾性队列研究调查了社区获得性脓毒症患者总医疗接触、院前和急诊部抗菌药延迟与在院死亡率之间的相关性。

目的:评价社区获得性脓毒症患者总医疗接触、院前和急诊部抗菌药延迟与在院死亡率之间的相关性。

设计:回顾性队列研究。

地点:2010年至2012年,宾夕法尼亚州西南部与21个急救医疗服务机构合作的9所医院。

患者:所有因社区获得性脓毒症而转院,并接受急救医疗服务的患者。

测量指标和主要结果:在58934例院前患者中,2683例为社区获得性脓毒症患者,在院死亡率为11%。首次医疗接触至抗菌药治疗(总医疗接触延迟)的中位时间为4.2 h(四分位间距,2.7~8.0 h),分为院前延迟中位时间0.52 h(四分位间距,0.40~0.66?h),急诊部延迟中位时间3.6 h(四分位间距,2.1~7.5?h)。在控制了其他风险因素的多变量分析中,总医疗接触延迟与在院死亡率增加相关(校正死亡比值比,每延迟1 h 为1.03 [95% CI,1.00~1.05];p<0.01)。其中,与急诊部延迟相关(p=0.04)但与院前延迟不相关(p=0.61)。

结论:抗菌药治疗中的总医疗接触和急诊部延迟均与社区获得性脓毒症患者的在院死亡率相关。

原始出处:
Seymour, C. W., et al.Delays From First Medical Contact to Antibiotic Administration for Sepsis. Crit Care Med .2017 May;45(5):759-765. doi: 10.1097/CCM.0000000000002264.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2042593, encodeId=9b3620425938b, content=<a href='/topic/show?id=999c88014ea' target=_blank style='color:#2F92EE;'>#获得性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88014, encryptionId=999c88014ea, topicName=获得性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Fri Mar 23 09:06:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214708, encodeId=182f214e0857, content=文章很好,拜读了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Jun 24 08:13:06 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212538, encodeId=180921253852, content=文章很好,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Jun 19 05:35:38 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395680, encodeId=0efb1395680a5, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74036, encryptionId=7a89e4036eb, topicName=社区)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Sun Jun 18 05:06:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516349, encodeId=30b71516349a2, content=<a href='/topic/show?id=a5598519866' target=_blank style='color:#2F92EE;'>#脓毒症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85198, encryptionId=a5598519866, topicName=脓毒症患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd7310955580, createdName=dlwang_26703130, createdTime=Sun Jun 18 05:06:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607655, encodeId=7c55160e655a4, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Jun 18 05:06:00 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-24 1e10c84am36(暂无匿称)

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    2017-06-19 1e10c84am36(暂无匿称)

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    0

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    2017-06-18 柳叶一刀